NORTHWEST BIO SHARED RESOURCE (NWBioSR) Northwest Bio Shared Resource (NWBioSR) provides patient consenting, human research biospecimen procurement, and annotation services. Patients are consented for (1) research use of biospecimens and electronic medical records-derived data and (2) enrollment in a registry of patients who consent to future contact for potential enrollment in clinical studies. All biospecimen and data handling is done under Institutional Review Board (IRB)-approved mechanisms. NWBioSR is organized under a Governance Committee with Consortium-wide representation and support. State-of-the-art information systems support operations, allowing broad Consortium access to: ? Registration of studies, associated IRB, and consent information ? Prospective identification of clinical samples, from which research biospecimens likely may be obtained, based on characteristics determined electronically prior to actual arrival of the clinical specimen in the hospital laboratory: 1. at the patient level, such as demographic information 2. at the visit level, such as tumor type and stage information 3. at the biospecimen level, such as aliquot stabilization time ? Procurement of research-only biospecimens, including blood draws obtained specifically for research and research-only biopsies ? Retrospective identification of clinical samples that pre-exist in the hospital laboratories and which may be used/subdivided for research (e.g., archival pathology blocks and slides as well as remnant blood ?leftover? in the laboratory medicine department from earlier clinical draws); ? Detailed annotation information including extensive extraction of medical records data as needed ? Generation of tissue microarrays as well as digital pathology image annotation and analysis of whole slide images ? Dissemination of biospecimen and annotation information through informatics efforts NWBioSR is a heavily-utilized facility, supporting a large number of clinical trials, translational research studies, Consortium biorepository collections, and external projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA015704-46
Application #
10125959
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-01
Project End
2024-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
46
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Georges, George E; Doney, Kris; Storb, Rainer (2018) Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment. Blood Adv 2:2020-2028
Duggan, Catherine; Tapsoba, Jean de Dieu; Stanczyk, Frank et al. (2018) Long-term weight loss maintenance, sex steroid hormones, and sex hormone-binding globulin. Menopause :
Yu, Ming; Maden, Sean K; Stachler, Matthew et al. (2018) Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis. Gut :
Lam, Hung-Ming; Corey, Eva (2018) Supraphysiological Testosterone Therapy as Treatment for Castration-Resistant Prostate Cancer. Front Oncol 8:167
Fowler, Kyle R; Hyppa, Randy W; Cromie, Gareth A et al. (2018) Physical basis for long-distance communication along meiotic chromosomes. Proc Natl Acad Sci U S A 115:E9333-E9342
Ogimi, Chikara; Xie, Hu; Leisenring, Wendy M et al. (2018) Initial High Viral Load Is Associated with Prolonged Shedding of Human Rhinovirus in Allogeneic Hematopoietic Cell Transplant Recipients. Biol Blood Marrow Transplant 24:2160-2163
Jeong, Kyoung Sook; Zhou, Jin; Griffin, Stephanie C et al. (2018) MicroRNA Changes in Firefighters. J Occup Environ Med 60:469-474
Appelbaum, Jacob; Wells, David; Hiatt, Joseph B et al. (2018) Fatal enteric plexus neuropathy after one dose of ipilimumab plus nivolumab: a case report. J Immunother Cancer 6:82
Blair, Kris M; Mears, Kevin S; Taylor, Jennifer A et al. (2018) The Helicobacter pylori cell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton. Mol Microbiol 110:114-127
Talarico, Sarah; Korson, Andrew S; Leverich, Christina K et al. (2018) High prevalence of Helicobacter pylori clarithromycin resistance mutations among Seattle patients measured by droplet digital PCR. Helicobacter 23:e12472

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