OVERALL The Fred Hutchinson/University of Washington Cancer Consortium (?the Consortium?) brings together more than 600 members with research interests in basic, clinical and public health sciences related to cancer. The goal of the Consortium is the elimination of cancer as a cause of suffering and death through more effective prevention, diagnostics, and treatment, deriving from fundamental insights into the biology of the disease. The extensive interdisciplinary collaboration among the partner institutions in the cancer research disciplines of basic, clinical, and public health sciences affords new opportunities to reduce suffering and mortality from cancer. The Consortium was established in 2002 to build upon the complementary strengths and resources of three partner institutions: the Fred Hutch, which has been an NCI-designated Comprehensive Cancer Center since 1976; the University of Washington, which has significant strength in cancer research, clinical care, and teaching; and Seattle Children?s, the major pediatric academic center in the region. In 2008, the Seattle Cancer Care Alliance, the cancer treatment center founded and equally co-owned by the three founding institutions, was formally added to the cancer center designation. The Consortium?s total funding base (direct dollars) is $242M, of which $117M is peer-reviewed, including $50M from the NCI. During the last grant period, over 170 new faculty members joined the Consortium, adding breadth and depth to our research and clinical capabilities. In the most recent year, we enrolled 1,338 patients onto interventional treatment trials, of which more than 50% were investigator-initiated. The ratio of accruals to newly registered patients was 28%. The Consortium serves a catchment area of 13 counties in western Washington. This equates to the region in which 83 percent of our patients reside. As the only NCI-designated comprehensive cancer center in a five- state region (Washington, Wyoming, Alaska, Montana and Idaho), we not only seek to serve the health needs of the catchment area through research, training, and outreach, but also to ensure high impact throughout the larger region. The Consortium continues to build upon historic strengths in basic cancer biology, immunology and transplantation, pathogen associated malignancies, tumor specific translational research, computational biology and studies of cancer etiology, prevention, and outcomes. The Consortium is well poised to continue its exceptional level of research in these areas. The CCSG continues to have a high impact on the Consortium, fostering new inter-institutional collaborations, strengthening the translational research platform, and intensifying research efforts on problems of the catchment area. Partner institutions contributed nearly $1.2 billion in institutional support during the last project period, including investments in our laboratory and clinical research infrastructure as well as in faculty recruitment and trainee support.

Public Health Relevance

OVERALL There were an estimated 1.7 million new cases of cancer in the United States in 2018, and an estimated 609,000 deaths from the disease. Cancer is the second leading cause of the death in the U.S. The goal of the Fred Hutchinson/University of Washington Cancer Consortium is the elimination of cancer as a cause of suffering and death through more effective prevention, diagnosis, and treatment, deriving from fundamental insights into the biology of the disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA015704-46S2
Application #
10292726
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
He, Min
Project Start
1997-01-01
Project End
2024-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
46
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Briant, Katherine J; Sanchez, Janeth I; Ibarra, Genoveva et al. (2018) Using a Culturally Tailored Intervention to Increase Colorectal Cancer Knowledge and Screening among Hispanics in a Rural Community. Cancer Epidemiol Biomarkers Prev 27:1283-1288
Xu, Chang; Nikolova, Olga; Basom, Ryan S et al. (2018) Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer. Clin Cancer Res 24:2828-2843
Miller, Chris P; Tsuchida, Connor; Zheng, Ying et al. (2018) A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. Neoplasia 20:610-620
Baker, K Scott; Syrjala, Karen L (2018) Long-term complications in adolescent and young adult leukemia survivors. Hematology Am Soc Hematol Educ Program 2018:146-153
Gavvovidis, Ioannis; Leisegang, Matthias; Willimsky, Gerald et al. (2018) Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus. Clin Cancer Res 24:3644-3655
Paulson, K G; Voillet, V; McAfee, M S et al. (2018) Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA. Nat Commun 9:3868
Puronen, Camille E; Cassaday, Ryan D; Stevenson, Philip A et al. (2018) Long-Term Follow-Up of 90Y-Ibritumomab Tiuxetan, Fludarabine, and Total Body Irradiation-Based Nonmyeloablative Allogeneic Transplant Conditioning for Persistent High-Risk B Cell Lymphoma. Biol Blood Marrow Transplant 24:2211-2215
Witzky, Anne; Hummels, Katherine R; Tollerson 2nd, Rodney et al. (2018) EF-P Posttranslational Modification Has Variable Impact on Polyproline Translation in Bacillus subtilis. MBio 9:
Rosenthal, Elisabeth A; Shirts, Brian H; Amendola, Laura M et al. (2018) Rare loss of function variants in candidate genes and risk of colorectal cancer. Hum Genet 137:795-806
Verboon, Jeffrey M; Decker, Jacob R; Nakamura, Mitsutoshi et al. (2018) Correction: Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis (doi:10.1242/211573). J Cell Sci 131:

Showing the most recent 10 out of 1267 publications