Abstract

Data Safety Monitoring Board In response to the NCI mandate, the JCCC Data and Safety Monitoring Board (DSMB) was constituted in January, 2001, and has been meeting weekly since then. Our complete DSMB plan was submitted to the NCI on 9/18/01 and approved 3/8/2002. The JCCC DSMB oversees the implementation of the data monitoring plans approved by the Protocol Review and Monitoring System/Institutional Scientific Review Committee (PRMS/ISPRC) and on file with the JCCC. The JCCC DSMB and PRMS/ISPRC have been significantly reorganized over the past 3 years and there is little overlap between the 2 committees. The administrative aspects of the DSMB are coordinated through the same office as the PRMS/ISPRC which allows for more effective communication and coordination. Partial funding for staff that supports the JCCC DSMB is requested in this application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016042-37
Application #
8374578
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
37
Fiscal Year
2012
Total Cost
$139,509
Indirect Cost
$66,852

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Epeldegui, Marta; Magpantay, Larry; Guo, Yu et al. (2018) A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma. AIDS 32:945-954
Hsu, Jeffrey J; Lu, Jinxiu; Umar, Soban et al. (2018) Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol 314:H1203-H1213
Woo, Jin Seok; Srikanth, Sonal; Kim, Kyun-Do et al. (2018) CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol 201:1174-1185
Patananan, Alexander N; Sercel, Alexander J; Teitell, Michael A (2018) More than a powerplant: the influence of mitochondrial transfer on the epigenome. Curr Opin Physiol 3:16-24
Heard, Jeffrey J; Phung, Ivy; Potes, Mark I et al. (2018) An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation. BMC Cancer 18:69
Kim, Roy Y; Mangu, Darian; Hoffman, Alexandria S et al. (2018) Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis. Brain 141:132-147
Pothoulakis, Charalabos; Torre-Rojas, Monica; Duran-Padilla, Marco A et al. (2018) CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis. Int J Cancer 142:334-346
Montecino-Rodriguez, Encarnacion; Casero, David; Fice, Michael et al. (2018) Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development. J Immunol 200:2046-2056
Black, David S; Cole, Steve W; Christodoulou, Georgia et al. (2018) Genomic mechanisms of fatigue in survivors of colorectal cancer. Cancer 124:2637-2644
Walser, Tonya C; Jing, Zhe; Tran, Linh M et al. (2018) Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res 78:1986-1999

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