The Patients and Survivors Program (PS) has 23 core members distributed across two themes. Members have appointments in four schools and eleven departments. During the current funding year, cancer-related funding for this program totaled $12M in total costs. Of this amount, peer-reviewed funding totaled $7.8M in total costs, including $3.5M from the NCI. As with other programs, the JCCC fosters many interactive activities and shared resources that support investigators in PS. During the current grant cycle, funds from the JCCC in the form of CCSG developmental funds, institutional support and philanthropic gifts to PS total $3,475,196. These funds supported seed grants, program leadership support, funding for special workshops and trainees. Sixteen PS members were recipients of JCCC support. PS members published 507 peer reviewed papers during the recent five-year renewal period, with 171 publications (34%) appearing in highimpact journals. The PS is highly interactive with 112 (22%) of its 507publications reflecting intraprogrammatic efforts and 58 (11%) reporting inter-programmatic collaborations. Accruals to therapeutic trials totaled 32, prevention trials 116, supportive care 1,751, epidemiologic/obs/outcome 16,921, ancillary/companion 185, and correlative 1,247 for a total of 20,252 subjects. PS has as its major goal the reduction in avoidable morbidity and mortality among patients with cancer and long-term survivors of cancer. The two main themes of the program are: 1) Quality-of-life/outcomes research, including late medical and psychosocial effects;and 2) Quality of cancer care, its measurement and evaluation. In both of these areas members focus on fundamental, investigator-initiated research, with extensive translational and transdisciplinary components. Program discoveries are being brought to the clinic and the community, as well as to broader testing arenas, such as Phase III clinical trials funded by the National Clinical Trials Network (NCTN). PS members are national and international leaders in survivorship, cancer outcomes assessment and quality of care research. Future program plans include continued translation and dissemination of research findings through implementation science and health policy engagement, as well as sustained emphasis on investigator-initiated research.

Public Health Relevance

The Patients and Survivors program JCCC members conduct translational and transdisciplinary research that emphasizes quality of life outcomes and quality of care for this target population. Improving health outcomes for individuals with a cancer diagnosis is a principal goal, which is achieved through descriptive and interventional research, with an emphasis on vulnerable populations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016042-39
Application #
8635437
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-12-01
Project End
2018-11-30
Budget Start
2014-03-07
Budget End
2014-11-30
Support Year
39
Fiscal Year
2014
Total Cost
$27,604
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Glenn, Beth A; Hamilton, Ann S; Nonzee, Narissa J et al. (2018) Obesity, physical activity, and dietary behaviors in an ethnically-diverse sample of cancer survivors with early onset disease. J Psychosoc Oncol 36:418-436
Tsai, Wen-Ting K; Wu, Anna M (2018) Aligning physics and physiology: Engineering antibodies for radionuclide delivery. J Labelled Comp Radiopharm 61:693-714
Lisova, Ksenia; Sergeev, Maxim; Evans-Axelsson, Susan et al. (2018) Microscale radiosynthesis, preclinical imaging and dosimetry study of [18F]AMBF3-TATE: A potential PET tracer for clinical imaging of somatostatin receptors. Nucl Med Biol 61:36-44
Chang, Yu-Ling; Rossetti, Maura; Vlamakis, Hera et al. (2018) A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. Mucosal Immunol :
Kiertscher, Sylvia M; Gangalum, Pallavi R; Ibrahim, Grace et al. (2018) A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers. J Neuroimmune Pharmacol 13:219-229
Jia, Qingmei; Bowen, Richard; Dillon, Barbara Jane et al. (2018) Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep 8:7009
Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Leoh, Lai Sum; Kim, Yoon Kyung; Candelaria, Pierre V et al. (2018) Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. J Immunol 200:3485-3494
Hicks, Michael R; Hiserodt, Julia; Paras, Katrina et al. (2018) ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol 20:46-57
Tsang, Eric J; Wu, Benjamin; Zuk, Patricia (2018) MAPK signaling has stage-dependent osteogenic effects on human adipose-derived stem cells in vitro. Connect Tissue Res 59:129-146

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