The Biostatistics, Analytical Support &Evaluation Shared Resource (BASE SR) provides comprehensive biostatistics and bioinformatics support to cancer-related research at UCLA. The BASE SR was established in 1994 and has been directed by Dr. Gang Li (CMI) since 2007. In addition to Li, the BASE SR also includes seven faculty members from the UCLA Departments of Biostatistics, Biomathematics, Human Genetics and Medicine, two staff biostatisticians and a program coordinator. All of these individuals have expertise in general biostatistics, the design and analysis of clinical trials and analysis of tissue arrays and next generation sequencing data. The BASE SR provides services for JCCC members who conduct both basic and clinical research. This includes critical support for the design of studies prior to grant submission, with statisticians supported as co-investigators if funding is obtained. In addition, the BASE SR provides support for JCCC protocol review, approval functions of the Internal Scientific Peer Review Committee (JCCC's PRMC), Data Safety and Monitoring Board and the Internal Quality Assurance Committee. The BASE SR also reviews clinical trials funded by pharmaceutical companies that are conducted in our clinical trials network, TRIO (Translational Research in Oncology). When needed, novel statistical methodology will be developed to facilitate studies. Peer-reviewed, funded research projects of JCCC investigators represent the highest priority. From 07/01/2011-06/30/2012, the BASE Shared Resource had 89 users, 66 of whom were JCCC members, representing seven Cancer Center Program Areas. Of the 89 member users, 49 had peer-reviewed funding and 17 did not have peer-reviewed funding. The role of the BASE SR in the facilitation of study design, data analysis, grant applications, protocol review, design and implementation of clinical trials and data management is central to the mission of JCCC.

Public Health Relevance

Statistical analysis is essential in order to interpret basic research results, such as complex data sets obtained from next generation sequencing, as well as to evaluate the outcome of clinical trials. The BASE SR provides such state-of-the-art services to support JCCC researchers in their quest to unravel the causes of cancer and to develop the most efficacious ways to treat it.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Lisova, Ksenia; Sergeev, Maxim; Evans-Axelsson, Susan et al. (2018) Microscale radiosynthesis, preclinical imaging and dosimetry study of [18F]AMBF3-TATE: A potential PET tracer for clinical imaging of somatostatin receptors. Nucl Med Biol 61:36-44
Chang, Yu-Ling; Rossetti, Maura; Vlamakis, Hera et al. (2018) A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. Mucosal Immunol :
Kiertscher, Sylvia M; Gangalum, Pallavi R; Ibrahim, Grace et al. (2018) A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers. J Neuroimmune Pharmacol 13:219-229
Jia, Qingmei; Bowen, Richard; Dillon, Barbara Jane et al. (2018) Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep 8:7009
Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Leoh, Lai Sum; Kim, Yoon Kyung; Candelaria, Pierre V et al. (2018) Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. J Immunol 200:3485-3494
Hicks, Michael R; Hiserodt, Julia; Paras, Katrina et al. (2018) ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol 20:46-57
Tsang, Eric J; Wu, Benjamin; Zuk, Patricia (2018) MAPK signaling has stage-dependent osteogenic effects on human adipose-derived stem cells in vitro. Connect Tissue Res 59:129-146
Waters, Lynnea R; Ahsan, Fasih M; Wolf, Dane M et al. (2018) Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. iScience 5:99-109
Van Dyk, Kathleen; Bower, Julienne E; Crespi, Catherine M et al. (2018) Cognitive function following breast cancer treatment and associations with concurrent symptoms. NPJ Breast Cancer 4:25

Showing the most recent 10 out of 767 publications