DEVELOPMENTAL FUNDS ABSTRACT Developmental Funds are an essential component of the UCLA Jonsson Comprehensive Cancer Center (JCCC) total resource package that Center leadership allocates for strategic imperatives to bolster high priority science and support the Center mission of accelerating discoveries to prevent and cure cancer. Use of CCSG Developmental Funds targets priorities identified in the 2019 ? 2023 JCCC Strategic Plan, leveraging combinations of additional resources obtained from philanthropy, foundations, UCLA schools and departments, and UCLA Health. Funds deployed for Center development initiatives that originate from the CCSG and other sources support multiple activities that enhance impactful JCCC research in its Los Angeles County catchment area and beyond. These deployments include funds for research faculty recruitment, for innovative transdisciplinary research through the competitive JCCC Intramural Awards Program, and for key initiatives, such as development of interventional early phase clinical research studies in identified high priority areas, or to enhance health care access and reduce disparities for Los Angeles County residents. To maximize the impact that leveraged Developmental Funds have on the Center and the community it serves, the JCCC embraces two overarching specific aims.
Aim 1 is to support cutting-edge cancer research as prioritized by the 2019 ? 2023 JCCC Strategic Plan through added resourcing of the competitive JCCC Intramural Awards Program. Supported strategic goals include development of highly innovative interventional early phase clinical studies in multiple tumor types informed through Center community outreach and engagement activities that identify top community needs.
Aim 2 is to leverage non-CCSG sources of support to fund additional intramural awards and to support recruitment and retention of faculty in areas elevated by the Center Strategic Plan. Areas identified as priorities include expanding clinical research and increasing inclusion of underserved populations, continuing to strengthen the JCCC Oncology Clinical Trials Network, initiatives focused on obesity and metabolism, translational theranostics, and cancer immunotherapy, as well as a focus on cancer biophysics and device commercialization.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016042-44
Application #
9936726
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
44
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Black, David S; Cole, Steve W; Christodoulou, Georgia et al. (2018) Genomic mechanisms of fatigue in survivors of colorectal cancer. Cancer 124:2637-2644
Walser, Tonya C; Jing, Zhe; Tran, Linh M et al. (2018) Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res 78:1986-1999
Chua, Bernadette Anne; Ngo, Jamie Ann; Situ, Kathy et al. (2018) Protein S and Gas6 induce efferocytosis of HIV-1-infected cells. Virology 515:176-190
Stanton, Annette L; Wiley, Joshua F; Krull, Jennifer L et al. (2018) Cancer-related coping processes as predictors of depressive symptoms, trajectories, and episodes. J Consult Clin Psychol 86:820-830
Glenn, Beth A; Hamilton, Ann S; Nonzee, Narissa J et al. (2018) Obesity, physical activity, and dietary behaviors in an ethnically-diverse sample of cancer survivors with early onset disease. J Psychosoc Oncol 36:418-436
Tsai, Wen-Ting K; Wu, Anna M (2018) Aligning physics and physiology: Engineering antibodies for radionuclide delivery. J Labelled Comp Radiopharm 61:693-714
Lisova, Ksenia; Sergeev, Maxim; Evans-Axelsson, Susan et al. (2018) Microscale radiosynthesis, preclinical imaging and dosimetry study of [18F]AMBF3-TATE: A potential PET tracer for clinical imaging of somatostatin receptors. Nucl Med Biol 61:36-44
Chang, Yu-Ling; Rossetti, Maura; Vlamakis, Hera et al. (2018) A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. Mucosal Immunol :
Jia, Qingmei; Bowen, Richard; Dillon, Barbara Jane et al. (2018) Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep 8:7009
Kiertscher, Sylvia M; Gangalum, Pallavi R; Ibrahim, Grace et al. (2018) A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers. J Neuroimmune Pharmacol 13:219-229

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