The Biostatistics Resource is a joint effort between Roswell Park Cancer Institute and theDepartment of Biostatistics at the University at Buffalo. The objective of the Biostatistics Resource is to bestrategically involved in the design, implementation, and analysis of scientific data generated by CCSGprogram members. This includes the articulation of study objectives, statement of hypotheses, thederivation of appropriate designs and models for the cost effective achievement of a study's objectives, theassurance that modern and appropriate statistical methods are used, monitoring interim and final analyses,and assisting in the writing of abstracts and manuscripts. The expertise provided by the staff ensures thatthe yield of useful information from the scientific studies conducted at Roswell Park Cancer Institute ismaximized while the costs are minimized. With Alan Hutson, PhD, Chair of Biostatistics at both theUniversity at Buffalo and Roswell Park Cancer Institute, Gregory Wilding, PhD, Assistant Chair, and severalnewly appointed PhD and MS level biostatisticians, the Resource has improved dramatically with respect toits technical expertise. This expertise spans biostatistics, molecular epidemiology, bioinformatics andstatistical genetics. Most Resource projects require the use of standard and commercially available tools.More recently, with the explosion of high throughput technologies, particular problems require an innovativesolution for which the Resource develops novel methodology and/or custom software. Within theBiostatistics Resource, the Biotechnical, Analytic and Visualization Resource (BAVR), headed by DanielGaile, PhD, has been developed to spearhead software development for complex statistical genetics andbioinformatics problems. The Resource's expanded and enhanced capabilities are made known to CCSGProgram leaders through referrals, by the Scientific Review Committee's requirement that protocols andgrant applications have input from a biostatistician, the mandate by funding agencies that proposals includestatistical designs with proper power analyses, formal seminars given by Resource staff, and presentationsat Program meetings. Strong synergies have also developed in terms of the relationship with the Statisticsand Data Coordinating center for the Gynecologic Oncology Group (GOG). In addition, the Resource hasbeen a fertile ground for training graduate students in biostatistics.The Resource is used by all six Programs. $251,993 in CCSG support is requested, representing22% of the total operating budget.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016056-32
Application #
7714434
Study Section
Subcommittee G - Education (NCI)
Project Start
2008-07-28
Project End
2013-04-30
Budget Start
2008-07-28
Budget End
2009-04-30
Support Year
32
Fiscal Year
2008
Total Cost
$301,331
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
824771034
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Chen, George L; Hahn, Theresa; Wilding, Gregory E et al. (2018) Reduced-Intensity Conditioning with Fludarabine, Melphalan, and Total Body Irradiation for Allogeneic Hematopoietic Cell Transplantation: The Effect of Increasing Melphalan Dose on Underlying Disease and Toxicity. Biol Blood Marrow Transplant :
Khoury, Thaer; Gaudioso, Carmelo; Fang, Yisheng V et al. (2018) The role of skin ulceration in breast carcinoma staging and outcome. Breast J 24:41-50
Griffiths, Elizabeth A; Srivastava, Pragya; Matsuzaki, Junko et al. (2018) NY-ESO-1 Vaccination in Combination with Decitabine Induces Antigen-Specific T-lymphocyte Responses in Patients with Myelodysplastic Syndrome. Clin Cancer Res 24:1019-1029
Irons, Eric E; Lau, Joseph T Y (2018) Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells. Front Immunol 9:2150
Travers, Mark J; Kulak, Jessica A; Vogl, Lisa (2018) Waterpipe cafés are hazardous to your health: Determination of a waterpipe specific calibration factor. Int J Hyg Environ Health 221:48-53
Khoury, Thaer; Nagrale, Vidya; Opyrchal, Mateusz et al. (2018) Prognostic Significance of Stromal Versus Intratumoral Infiltrating Lymphocytes in Different Subtypes of Breast Cancer Treated With Cytotoxic Neoadjuvant Chemotherapy. Appl Immunohistochem Mol Morphol 26:523-532
Yang, Lu; Bhattacharya, Arup; Li, Yun et al. (2018) Anticoagulants inhibit proteolytic clearance of plasma amyloid beta. Oncotarget 9:5614-5626
Hanif, Ahmad; Wang, Eunice S; Thompson, James E et al. (2018) Combining blinatumomab with targeted therapy for BCR-ABL mutant relapsed/refractory acute lymphoblastic leukemia. Leuk Lymphoma 59:2011-2013
Welliver, R Ross; Polanco, Jessie J; Seidman, Richard A et al. (2018) Muscarinic receptor M3R signaling prevents efficient remyelination by human and mouse oligodendrocyte progenitor cells. J Neurosci :
Widman, Christy A; Rodriguez, Elisa M; Saad-Harfouche, Frances et al. (2018) Clinician and Parent Perspectives on Educational Needs for Increasing Adolescent HPV Vaccination. J Cancer Educ 33:332-339

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