The Genetics Program (GN) is committed to fostering intra- and inter-programmatic and collaborative innovative studies that focus on functional genomics. The overall goal of the GN Program is to identify and characterize genetic and genomic changes that drive and/or predict cancer initiation, progression or therapeutic response, thus developing new therapeutic targets. Historically, much of the focus in this Program has been in basic research and discovery;more recently the goal has been broadened to encourage involvement by Program members in translational and clinical studies. The Program's central themes are 1) Cancer Gene, Signatures and Pathway Discovery;2) Epigenetics and Genomic Instability, and 3) Mouse Models of Cancer. The program is led by Irwin Gelman. PhD, who has strong interests in basic and translational aspects of cancer genetics. The GN Program has longstanding strength in basic cancer genetic discovery and functional genomics research. Dr. Gelman's leadership in translating this to new drug/pathway targets and predictive genetic tests has been facilitated by robust inter- and intra-programmatic collaborations, monthly meetings and twice-yearly retreats that emphasize interaction with clinicians, population scientists and translational researchers. Innovative new projects are promoted by the establishment of cutting-edge genetic screening, sequencing and bioinformatics platforms, and by GN-led projects that emphasize highly collaborative studies that will yield new grants and/or high-impact publications. Program members have published 321 publications since 2008;20% were inter-programmatic and 19% were intra-programmatic;22 publications were in journals with an impact factor >10. Current annual total peer-reviewed funding is $7.9M, of which $3.8M is NCI, and the total extramural research funding is $9.2M. The GN Program has 24 members with expertise in mouse models of cancer, molecular analysis of human cancer, genetics and pathways controlling metastasis, epigenomics, bioinformatics and molecular pathology, all of which are fully integrated into the themes within the Program. The Program members come from seven departments at RPCI.

Public Health Relevance

Leadership has reestablished focus on programmatic collaboration to promote translational genetic and genomic research through interactions between basic scientists and clinical investigators. The GN Program bridges cutting-edge genomics and bioinformatics expertise, carefully developed tissue banks and medical informatics, to drive development of team-science approaches to hypothesis-driven research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016056-37
Application #
8738362
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-06-16
Project End
2019-04-30
Budget Start
2014-06-26
Budget End
2015-04-30
Support Year
37
Fiscal Year
2014
Total Cost
$19,598
Indirect Cost
$7,752
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
824771034
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Eng, Diana G; Kaverina, Natalya V; Schneider, Remington R S et al. (2018) Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing. Kidney Int 93:1240-1246
Ling, Xiang; Wu, Wenjie; Fan, Chuandong et al. (2018) An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer. J Exp Clin Cancer Res 37:240
Chung, Sejin; Vail, Paris J; Witkiewicz, Agnieszka K et al. (2018) Coordinately targeting cell cycle checkpoint functions in integrated models of pancreatic cancer. Clin Cancer Res :
Mohammadpour, Hemn; O'Neil, Rachel; Qiu, Jingxin et al. (2018) Blockade of Host ?2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs. J Immunol 200:2479-2488
Hsu, Alice H; Lum, Michelle A; Shim, Kang-Sup et al. (2018) Crosstalk between PKC? and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep 24:655-669
Sandlesh, Poorva; Juang, Thierry; Safina, Alfiya et al. (2018) Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. PLoS One 13:e0199785
Zhang, Dingxiao; Zhao, Shuhong; Li, Xinyun et al. (2018) Prostate Luminal Progenitor Cells in Development and Cancer. Trends Cancer 4:769-783
Hong, Chi-Chen; Sucheston-Campbell, Lara E; Liu, Song et al. (2018) Genetic Variants in Immune-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev 27:321-330
Damayanti, Nur P; Budka, Justin A; Khella, Heba W Z et al. (2018) Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma. Clin Cancer Res 24:5977-5989
Mayor, Paul; Starbuck, Kristen; Zsiros, Emese (2018) Adoptive cell transfer using autologous tumor infiltrating lymphocytes in gynecologic malignancies. Gynecol Oncol 150:361-369

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