The Laboratory Animal Shared Resource (LAR) provides the entire spectrum of animal-related research services, including specialized veterinary medical care, expert animal husbandry, diagnostic and surgical services, imaging resources and training of investigators and laboratory personnel. The LAR promotes the humane care and use of laboratory animals in support of basic and translational research. Although the majority of animal care services provided by LAR are related to mice and rats, the animal program at RPCI has been expanded to include larger species including rabbits, woodchucks, dogs and pigs. Two buildings are designated for the LAR. The main site is the four-story 45,000 net square foot (nsf) Vivarium, which opened in 1998, located in the Medical Research Complex. An additional 5,000 nsf is utilized in the adjacent Cancer Cell Center. The LAR Facility Director and Attending Veterinarian, Sandra (Buitrago) Sexton DVM, oversees the Veterinary Program to a standard that ensures that all services meet or exceed the criteria set in the LAR's AAALAC accreditation. She is assisted by a qualified support staff for administration and management of the facility and for provision of specialized veterinary medical care. Dr. Sexton provides training and education programs for researchers on proper care and use of animals, including: Clinical care of laboratory animals (proper handling, postoperative care, analgesia and surgery techniques) A preventive animal health-monitoring program Coordination of import/export of animals to and from other facilities, promoting a strong collaborative relationship with scientists and clinicians at other institutions with major focus in cancer research. A total of 46 staff members comprise the LAR workforce, with CCSG direct effort of 5.86 FTE. Continued support through the NCI permits the Resource to provide a standard of animal care that exceeds applicable state and federal regulations, maintains full AAALAC International accreditation, and furnishes investigators with a comprehensive program for safe, appropriate and cost-effective research animal use. Prioritization for Resource utilization is 1) peer-review-funded CCSG members;2) non-peer-review-funded CCSG members; 3) non-members and academic collaborators;and 4) external users. During the reporting period, the Laboratory Animal Shared Resource has served 83 members from 6 research programs, with 72% utilization by CCSG members with peer reviewed funding. The CCSG support provides 4% of the overall proposed budget.

Public Health Relevance

All transitional research requires pre-clinical testing using laboratory animals prior to moving to clinical trials with humans. New faculty members have been recruited by the Institute to enhance its excellence in basic, translational and cancer research programs, contributing to an increased demand for the LAR. These positive developments have contributed to scientific and clinical growth at the cancer center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016056-37
Application #
8738384
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-06-16
Project End
2019-04-30
Budget Start
2014-06-26
Budget End
2015-04-30
Support Year
37
Fiscal Year
2014
Total Cost
$203,358
Indirect Cost
$80,436
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
824771034
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Block, Matthew S; Vierkant, Robert A; Rambau, Peter F et al. (2018) MyD88 and TLR4 Expression in Epithelial Ovarian Cancer. Mayo Clin Proc 93:307-320
Li, Qiuhui; Deng, Qu; Chao, Hsueh-Ping et al. (2018) Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nat Commun 9:3600
Rossetti, Stefano; Wierzbicki, Andrzej J; Sacchi, Nicoletta (2018) Undermining ribosomal RNA transcription in both the nucleolus and mitochondrion: an offbeat approach to target MYC-driven cancer. Oncotarget 9:5016-5031
Mett, V; Komarova, E A; Greene, K et al. (2018) Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy. Oncogene 37:439-449
Long, Mark D; Singh, Prashant K; Russell, James R et al. (2018) The miR-96 and RAR? signaling axis governs androgen signaling and prostate cancer progression. Oncogene :
Kawaguchi, Tstutomu; Yan, Li; Qi, Qianya et al. (2018) Novel MicroRNA-Based Risk Score Identified by Integrated Analyses to Predict Metastasis and Poor Prognosis in Breast Cancer. Ann Surg Oncol 25:4037-4046
Mussell, Ashley L; Denson, Kayla E; Shen, He et al. (2018) Loss of KIBRA function activates EGFR signaling by inducing AREG. Oncotarget 9:29975-29984
Hirose, Yuki; Nagahashi, Masayuki; Katsuta, Eriko et al. (2018) Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis. Sci Rep 8:10814
Vexler, Albert; Yu, Jihnhee; Zhao, Yang et al. (2018) Expected p-values in light of an ROC curve analysis applied to optimal multiple testing procedures. Stat Methods Med Res 27:3560-3576
Samuel, Sandeep; Mukherjee, Sarbajit; Ammannagari, Nischala et al. (2018) Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: A population-based study. PLoS One 13:e0198809

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