In 2008 the OSUCCC reorganized the OSUCCC Tissue Procurement Shared Resource into the Biorepository and Biospecimen Resource (BBR). The goal of the Biorepository and Biospecimen Resource is to provide a well-organized and centralized biorepository that meets the best practices of the NCI for high quality biospecimens for cancer research. The BBR is directed by Dr. Scott Jewell who has extensive experience in the policy, management and operations in tissue procurement and banking. The BBR oversees the procurement of malignant, benign, diseased and uninvolved (normal) tissues from solid tumors for OSUCCC researchers and has expanded into a centralized biospecimen banking system with universal patient informed consent for the donation of biospecimens (tissues, bloods, and fluids) and annotated clinical data for future research. Using caGRID technology, these specimens are linked with annotated patient health and medical information, thereby enhancing the quality and usability of these biospecimens for research. The BBR has collected over 10,000 samples in the last 10 months .since the inception of patient informed consent and an additional 2,500+ tissue specimens for immediate use to investigators. During this reporting period (2004-2009) the BBR provided all six OSUCCC Scientific Programs with more than 11,000 tissue specimens. Valued features of the BBR include: a consent team that obtains patient informed consent at the point of registration; patient medical and health information that is annotated to the biospecimen; centralized management of the collection; processing and storage of the biospecimens; and security and protection of the resource, such as empty backup freezers, diesel generator for electrical backup protection, 24/7 monitoring of all freezers, and an emergency response team. The BBR utilizes caTissueSuite (a caBIG application) to record and monitor the biorepository inventory. A web-based application has been developed that will allow researchers to determine if tissue exists in the BBR with particular phenotypic characteristics. As informed consent expands to all clinical sites, this will create a vast repository of viable research biospecimens linked with annotated clinical data, providing an unparalleled resource for OSUCCC investigators. Outstanding institutional support has been critical to the implementation of the universal informed consent process and has ensured the continued growth and success of this highly valued shared resource. This past year, although 75.26% of the BBR usage was from CCSG peer-reviewed, funded OSUCCC investigators and overall OSUCCC usage was 96.77%, only 24.9% of the BBR budgetary support came from the CCSG.
The BBR supports high quality science in the OSUCCC through both the procurement of malignant, benign, diseased and uninvolved (normal) tissues from patients with solid tumors for OSUCCC researchers in a centralized and coordinated biospecimen banking system. Universal patient informed consent for the donation of biospecimens enhances outstanding cancer research through the oversight and collection of high quality human biospecimens annotated with patient health and medical information.
|Scoville, Steven D; Nalin, Ansel P; Chen, Luxi et al. (2018) Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function. Blood 132:1792-1804|
|McMillan, Elizabeth A; Ryu, Myung-Jeom; Diep, Caroline H et al. (2018) Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell 173:864-878.e29|
|Schimizzi, Gregory V; Jin, Linda X; Davidson 4th, Jesse T et al. (2018) Outcomes after vascular resection during curative-intent resection for hilar cholangiocarcinoma: a multi-institution study from the US extrahepatic biliary malignancy consortium. HPB (Oxford) 20:332-339|
|Fu, Xinping; Tao, Lihua; Wang, Pin-Yi et al. (2018) Comparison of infectivity and spread between HSV-1 and HSV-2 based oncolytic viruses on tumor cells with different receptor expression profiles. Oncotarget 9:21348-21358|
|Brewington, Beatrice Y; Shao, Yusra F; Davidorf, Fredrick H et al. (2018) Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions. Clin Ophthalmol 12:925-934|
|Doogan, Nathan J; Cooper, Sarah; Quisenberry, Amanda J et al. (2018) The role of travel distance and price promotions in tobacco product purchase quantity. Health Place 51:151-157|
|Byrd, John C; Ruppert, Amy S; Heerema, Nyla A et al. (2018) Lenalidomide consolidation benefits patients with CLL receiving chemoimmunotherapy: results for CALGB 10404 (Alliance). Blood Adv 2:1705-1718|
|Oblinger, Janet L; Burns, Sarah S; Huang, Jie et al. (2018) Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation. Exp Neurol 299:299-307|
|Shu, Yi; Yin, Hongran; Rajabi, Mehdi et al. (2018) RNA-based micelles: A novel platform for paclitaxel loading and delivery. J Control Release 276:17-29|
|Stephens, Julie A; Fisher, James L; Krok-Schoen, Jessica L et al. (2018) Esophageal Adenocarcinoma: Opportunities for Targeted Prevention in Ohio. Clin Med Insights Gastroenterol 11:1179552218791170|
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