PROJECT-003: MOLECULAR BIOLOGY AND CANCER GENETICS PROGRAM (MBCG) PROJECT SUMMARY / ABSTRACT The Molecular Biology & Cancer Genetics (MBCG) Program at The Ohio State University Comprehensive Cancer Center (OSUCCC), led by Michael Ostrowski, PhD and Matthew Ringel, MD, unites a highly productive, collaborative and cancer focused team of 44 basic and translational scientists representing 7 colleges and 18 academic departments at The Ohio State University. Program science is centered in four major cancer-focused scientific themes: small non-coding RNAs and cancer, human cancer genetics/genomics, signal transduction and therapeutic resistance, and tumor microenvironment. Program members utilize state-of-the-art approaches to 1) identify genes and pathways that fuel tumor cell initiation and growth, and 2) provide mechanistic details of how these genes and pathways contribute to tumor progression and therapeutic resistance. Our overall goal is to define the mechanisms that account for the association between genes and cancer and to exploit this knowledge in order to reduce the incidence of death from cancer.
The Specific Aims of the MBCG Program are: 1) to identify human genes, including non-coding genes such as those encoding microRNAs, that either through direct mutations or epigenetic mechanisms, result in an increased predisposition to cancer; 2) to determine the molecular mechanisms underlying the expression and function of the genes contributing to normal development, cancer progression, and therapeutic resistance; 3) to utilize the knowledge gained from gene identification and gene functions in tumorigenesis in order to reduce the incidence of death from cancer. During the prior funding period of the OSUCCC P30 CCSG, MBCG Program members published 810 research papers, including 104 high impact (> 10) manuscripts in journals such as Cell, Cancer Cell, Science, Nature Medicine, Nature Cell Biology, Journal of Clinical Oncology, and Journal of Clinical Investigation. There is extensive collaboration, with 21% intra-programmatic, 31% inter-programmatic, and 66% multi- institutional publications. Overall, 81% of MBCG publications are collaborative. MBCG Program members are principal investigators (PIs) on seven NCI programmatic grants, including a P01 and U01 in breast cancer (P01 CA097189, U01 CA154200), a P01 and P50 SPORE in thyroid cancer (P01 CA124570, P50 CA168505), a P01 in epigenetics (CA129242) and two U01s in lung cancer (U01 CA152758, U01 CA166905). They are PIs on CCSG-approved grants whose direct funding is currently $9.39 million, with $7.5 million in NCI funding (80% of total CCSG-approved funding). Program members are principal investigators on 21 active protocols that have accrued 5760 patients over the past five years. MBCG studies are predominantly interventional but non-therapeutic, and non-interventional as most of our interventional therapeutic work is accomplished collaboratively within the Translational Therapeutics and Leukemia Research Programs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016058-40
Application #
9000521
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-09-12
Project End
2020-11-30
Budget Start
2016-02-09
Budget End
2016-11-30
Support Year
40
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Barredo, Julio C; Hastings, Caroline; Lu, Xiamin et al. (2018) Isolated late testicular relapse of B-cell acute lymphoblastic leukemia treated with intensive systemic chemotherapy and response-based testicular radiation: A Children's Oncology Group study. Pediatr Blood Cancer 65:e26928
Kim, So-Youn; Nair, Devi M; Romero, Megan et al. (2018) Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death Differ :
Yadav, Marshleen; Song, Feifei; Huang, Jason et al. (2018) Ocimum flavone Orientin as a countermeasure for thrombocytopenia. Sci Rep 8:5075
Siegel, Marni B; He, Xiaping; Hoadley, Katherine A et al. (2018) Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer. J Clin Invest 128:1371-1383
White, Brian S; Lanc, Irena; O'Neal, Julie et al. (2018) A multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5. Blood Cancer J 8:35
Owen, Dwight; Chaft, Jamie E (2018) Immunotherapy in surgically resectable non-small cell lung cancer. J Thorac Dis 10:S404-S411
O'Brien, Susan M; Jaglowski, Samantha; Byrd, John C et al. (2018) Prognostic Factors for Complete Response to Ibrutinib in Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of 2 Clinical Trials. JAMA Oncol 4:712-716
Guo, Sijin; Piao, Xijun; Li, Hui et al. (2018) Methods for construction and characterization of simple or special multifunctional RNA nanoparticles based on the 3WJ of phi29 DNA packaging motor. Methods 143:121-133
Sadowski, Abbey R; Gardner, Heather L; Borgatti, Antonella et al. (2018) Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma. BMC Vet Res 14:250
Borniger, Jeremy C; Walker Ii, William H; Surbhi et al. (2018) A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer. Cell Metab 28:118-129.e5

Showing the most recent 10 out of 2602 publications