CORE-019: EARLY PHASE CLINICAL RESEARCH SUPPORT (EPCRS) PROJECT SUMMARY / ABSTRACT A major area of institutional support for clinical cancer research is for investigator-initiated trials. The arrival of new investigators into the OSUCCC, the increased attention paid to translational research and changes in the funding landscape of clinical trials requires that there be a mechanism for funding investigator initiated studies of novel agents and/or novel design. The support of innovative Phase I trials and pilot studies was previously supported by the CCSG-mandated Protocol Specific Research Support mechanism. With the recent changes in the CCSG guidelines, the Early Phase Clinical Research Support (EPCRS) mechanism has been employed since late 2013 as a means of stimulating the conduct of early phase, investigator-initiated studies. The EPCRS process is overseen by Dr. William Carson, the Associate Director for Clinical Research (ADCR). Investigators are informed of this OSUCCC support mechanism via official communications from OSUCCC administration and the Disease Specific Research Group (DSRG) leaders. There is a formal application process which is conducted quarterly. Proposals are reviewed by a panel, chaired by the ADCR, Dr. William Carson. Successful applications are selected for CCSG support in the form of research nurse or data management assistance from the CCC supported Clinical Trials Office (CTO). On average 1-3 studies have been approved for support each quarter. In the current funding cycle, a total of 13 studies have been supported by the EPCRS and have accrued a total of 175 patients in the last year. In addition, to EPCRS, the OSUCCC has a formal, peer-reviewed mechanism, called the Intramural Research Program (IRP), to channel developmental funds from Pelotonia, our annual bicycle fundraising event, into bench to beside research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016058-43
Application #
9632735
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
43
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Sizemore, Gina M; Balakrishnan, Subhasree; Thies, Katie A et al. (2018) Stromal PTEN determines mammary epithelial response to radiotherapy. Nat Commun 9:2783
Zeng, Rong; Liu, Yi; Jiang, Zhao-Jing et al. (2018) EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma. Int J Oncol :
Kotlarek, Marta; Kubiak, Anna; Czetwerty?ska, Ma?gorzata et al. (2018) The rs2910164 Genetic Variant of miR-146a-3p Is Associated with Increased Overall Mortality in Patients with Follicular Variant Papillary Thyroid Carcinoma. Int J Mol Sci 19:
Li, Feng; Malli, Ahmad; Cruz-Monserrate, Zobeida et al. (2018) Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts. World J Gastrointest Endosc 10:1-9
He, Huiling; Li, Wei; Yan, Pearlly et al. (2018) Identification of a Recurrent LMO7-BRAF Fusion in Papillary Thyroid Carcinoma. Thyroid 28:748-754
Moshiri, Jasmine; Kaur, Darpan; Hambira, Chido M et al. (2018) Identification of a Small Molecule Anti-biofilm Agent Against Salmonella enterica. Front Microbiol 9:2804
Serna, Vanida A; Wu, Xin; Qiang, Wenan et al. (2018) Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo. Endocr Relat Cancer 25:747-759
Dabrowski, Konrad; Miller, Mackenzie (2018) Contested Paradigm in Raising Zebrafish (Danio rerio). Zebrafish 15:295-309
Krok-Schoen, Jessica L; Fisher, James L; Baltic, Ryan D et al. (2018) White-Black Differences in Cancer Incidence, Stage at Diagnosis, and Survival Among Older Adults. J Aging Health 30:863-881
Killian, Jackson A; Topiwala, Taha M; Pelletier, Alex R et al. (2018) FuSpot: a web-based tool for visual evaluation of fusion candidates. BMC Genomics 19:139

Showing the most recent 10 out of 2602 publications