CORE-011: NUTRIENT AND PHYTOCHEMICAL ANALYTICS SHARED RESOURCE (NPASR) PROJECT SUMMARY / ABSTRACT Diet, nutrition and lifestyle contribute significantly to the etiology of cancer and may play a role in cancer prevention, enhancing efficacy of cancer therapy and promoting survivorship. The rapid growth in funded cancer studies of dietary and nutritional components over recent years led to the proposal of a developing Nutrient and Phytochemical Analytic Shared Resource (NPASR) at the last review. Originally supported by CCSG Developmental Funds, this service is now being proposed as an established CCSG Shared Resource to provide OSUCCC members with expert bioanalytical method development and quantitative analysis of foods and biospecimens. The NPASR is located in the College of Food, Agricultural, and Environmental Sciences (CFAES). The director (Dr. Schwartz (MCC)) and research scientist (Dr. Riedl) established the initial core services. The capabilities of the NPASR have been enhanced in recent years through substantial OSUCCC support for both salary and equipment, especially the recent purchase of Agilent 1290 UHPLC-Q-TOF 6550. Protocols are developed consistent with Good Laboratory Practices. Major services for the NPASR include: analytical method development and validation; nutrient and phytochemical analysis of foods; targeted metabolomics and biomarker analysis in cell cultures, experimental animals and humans; and, untargeted metabolomics.
The Specific Aims of NPASR are to: 1) provide expert, leading-edge bioanalytical method development and quantitative analysis of nutrients and bioactive phytochemicals in foodstuffs and carcinogen exposures; 2) conduct targeted quantitative analysis of nutrients, bioactive phytochemicals and their metabolites in biological samples generated from cell and animal experiments and human clinical trials using HPLC-MS/MS techniques; and, as a developing aim, 3) perform untargeted metabolomics experiments for cancer-related prevention studies. NPASR, since its inception in 2010, NPASR has supported 12 OSUCCC members from 3 of the 5 OSUCCC programs (60% of the usage), all focused on cancer prevention. These OSUCCC members are from the Colleges of Medicine, Public Health, Pharmacy, Education and Human Ecology, and Arts & Sciences. NPASR has provided services for 45 cancer related publications and has supported projects for 12 NCI-funded grants, including four programmatic grants. What is unique about NPASR is that it couples high quality analytical services with experts who understand food composition, metabolism, and dietary interventions as applied to cancer prevention research. Along with developing the capability for several large funded projects, future growth areas include untargeted metabolomics, microbiome studies and studies of lipidomics and eicosanoid profiling. The NPASR leverages extensive institutional support and seeks 21.2% support from CCSG funds. The Nutrient and Phytochemical Shared Resource is part of the Analytics Grouping.
|Rolfo, Christian; Mack, Philip C; Scagliotti, Giorgio V et al. (2018) Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC. J Thorac Oncol 13:1248-1268|
|Ren, Yulin; Gallucci, Judith C; Li, Xinxin et al. (2018) Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens. J Nat Prod 81:554-561|
|McDonald, J Tyson; Kritharis, Athena; Beheshti, Afshin et al. (2018) Comparative oncology DNA sequencing of canine T cell lymphoma via human hotspot panel. Oncotarget 9:22693-22702|
|Nguyen, Phuong; Wuthrick, Evan; Chablani, Priyanka et al. (2018) Does Delaying Surgical Resection After Neoadjuvant Chemoradiation Impact Clinical Outcomes in Locally Advanced Rectal Adenocarcinoma?: A Single-Institution Experience. Am J Clin Oncol 41:140-146|
|Elchuri, Sailaja V; Rajasekaran, Swetha; Miles, Wayne O (2018) RNA-Sequencing of Primary Retinoblastoma Tumors Provides New Insights and Challenges Into Tumor Development. Front Genet 9:170|
|Reiff, Sean D; Muhowski, Elizabeth M; Guinn, Daphne et al. (2018) Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL. Blood 132:1039-1049|
|Nabar, Gauri M; Mahajan, Kalpesh D; Calhoun, Mark A et al. (2018) Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery. Int J Nanomedicine 13:351-366|
|Tang, Xiaowen; Yang, Lin; Li, Zheng et al. (2018) First-in-man clinical trial of CAR NK-92 cells: safety test of CD33-CAR NK-92 cells in patients with relapsed and refractory acute myeloid leukemia. Am J Cancer Res 8:1083-1089|
|Lai, Xiulan; Stiff, Andrew; Duggan, Megan et al. (2018) Modeling combination therapy for breast cancer with BET and immune checkpoint inhibitors. Proc Natl Acad Sci U S A 115:5534-5539|
|Reeves, Katherine W; Pennell, Michael; Foraker, Randi E et al. (2018) Predictors of vasomotor symptoms among breast cancer survivors. J Cancer Surviv 12:379-387|
Showing the most recent 10 out of 2602 publications