? CANCER BIOLOGY (CB) The Cancer Biology (CB) Program at The Ohio State University Comprehensive Cancer Center (OSUCCC), led by Matthew Ringel, MD, and Philip Tsichlis, MD, has 56 members from 21 Departments and 5 OSU Colleges (Arts & Sciences, Engineering, Medicine, Public Health, and Veterinary Medicine). CB investigators focus on three thematic scientific areas of focus: 1) Defining the roles of non-coding RNAs, gene mutations, and regulation of gene expression in cancer development and progression; 2) Determining new mechanisms of altered cancer cell signal transduction and DNA damage repair responses, and responses to therapeutic challenges; and 3) integrating cancer biology into complex model systems, computational biology, and human tissues to study mechanisms of cancer progression. The overall vision of the CB Program is to exploit the fundamental mechanistic knowledge gained in these areas of strategic emphasis to improve cancer prevention, treatment, and outcomes through collaborations.
The Specific Aims of the CB Program focus on: 1) Mechanisms of cancer initiation. Studies focus on identification and characterization of mutations, epigenetic changes, and the expression and function of coding and non-coding genes. The goal will be to discover novel mechanisms of cancer predisposition and initiation, with an emphasis on translation; 2) Mechanisms and markers of response and resistance to therapeutic and environmental challenges. Research focuses on cancer responses to radiation and chemotherapy/targeted therapy with emphasis on signaling, DNA damage and the response to hypoxia and anti-tumor immunity; and, 3) Mechanisms of cancer progression. Studies focus on the identification of potentially targetable mechanisms that regulate tumor progression and metastasis. CB Program members published 645 cancer-relevant manuscripts between 12/01/14 and 11/30/19. Of these, 10% were intra- programmatic (multiple authors from CC Program), 25% were inter-programmatic (authors from multiple OSUCCC Programs), and 73% were multi-institutional (authors from both CB and another institution). The total collaborative publications is 81%. CB Program funding stands at $8.0M in overall direct, cancer-focused funding, of which $7.7M is peer-reviewed, including $6.7M direct funding from NIH ($5.1M from NCI). Over the last 5 years, CB Program members have accrued 1,522 participants to non-therapeutic/non-interventional trials comprised of investigator-driven IRB-approved biospecimen repositories. As a basic science program, CB is designed for member involvement in therapeutic trials through inter-programmatic collaboration. Future plans for the CB Program include innovation and growth in cancer immunology, translational genomics leveraging inter-institutional resources such as ORIEN, and identification of new targets, the development and growth of the cancer engineering research, and for cancer prevention by increasing basic science studies for the development of cancer and genetic predispositions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016058-45
Application #
10089993
Study Section
Subcommittee H - Clinical Groups (NCI)
Project Start
1997-09-12
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Zhang, Bin; Nguyen, Le Xuan Truong; Li, Ling et al. (2018) Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Nat Med 24:450-462
Tasselli, Giorgia; Filippucci, Sara; Borsella, Elisabetta et al. (2018) Yeast lipids from cardoon stalks, stranded driftwood and olive tree pruning residues as possible extra sources of oils for producing biofuels and biochemicals. Biotechnol Biofuels 11:147
Moliva, J I; Hossfeld, A P; Canan, C H et al. (2018) Exposure to human alveolar lining fluid enhances Mycobacterium bovis BCG vaccine efficacy against Mycobacterium tuberculosis infection in a CD8+ T-cell-dependent manner. Mucosal Immunol 11:968-978
Suarez-Kelly, Lorena P; Akagi, Keiko; Reeser, Julie W et al. (2018) Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity. Cold Spring Harb Mol Case Stud 4:
Malpeli, Giorgio; Barbi, Stefano; Greco, Corinna et al. (2018) MicroRNA signatures and Foxp3+ cell count correlate with relapse occurrence in follicular lymphoma. Oncotarget 9:19961-19979
Talbert, Erin E; Lewis, Heather L; Farren, Matthew R et al. (2018) Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients. J Cachexia Sarcopenia Muscle 9:358-368
Wang, Jin-Ting; Xie, Wen-Quan; Liu, Fa-Quan et al. (2018) NADH protect against radiation enteritis by enhancing autophagy and inhibiting inflammation through PI3K/AKT pathway. Am J Transl Res 10:1713-1721
Karpurapu, Manjula; Lee, Yong Gyu; Qian, Ziqing et al. (2018) Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis. Oncotarget 9:10606-10620
Norquist, Barbara M; Brady, Mark F; Harrell, Maria I et al. (2018) Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study. Clin Cancer Res 24:777-783
Addison, Daniel; Lawler, Patrick R; Emami, Hamed et al. (2018) Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer. J Stroke 20:71-79

Showing the most recent 10 out of 2602 publications