Core - Clinical Research

Roberts, John David

Abstract

The Clinical Research Shared Resource consists of the Director, the Office for Clinical Research (centralized protocol office), eight discipline-oriented RN/CRA teams, and a computer programmer and analyst team. In addition, the Clinical Trials Review Committee (PRMS) and its sub-committee, the Monitoring Committee, operate out of the shared resource office. The activities of the Shared Resource provide broad support of clinical cancer research and require the coordinated activities of more than 17 FTEs; it supports a broad range of research with diverse sponsors. The shared resource predominantly is supported by grants, contracts, and MCC discretionary funds. Limited CCSG support (0.95 FTE) is requested for the Director, Administrator, RN consultant, Programmer, and Analyst positions of this resource. These personnel serve leadership, coordination, and quality assurance roles that enhance the efficiency and value of individual research projects or affiliations. CCSG support also is requested for two other aspects of the clinical research operation, specifically, Protocol- specific Research Support (section 9.10; 1.80 1TI,E) and PRMS (section 9.9; 0.35 FTE).

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 2P30CA016059-21
• Application #: 6101747
• Project Start: 1999-02-19
• Project End: 1999-11-30
• Budget Start: 1998-10-01
• Budget End: 1999-09-30
• Support Year: 21
• Fiscal Year: 1999

Institution

• Name: Virginia Commonwealth University
• City: Richmond
• State: VA
• Country: United States
• Zip Code: 23298

Publications

Radwa?ska, Malwina J; Jaskó?owski, Mateusz; Davydova, Elena et al. (2018) The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab. Acta Crystallogr D Struct Biol 74:681-689

Curry, Zachary A; Wilkerson, Jenny L; Bagdas, Deniz et al. (2018) Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy. J Pharmacol Exp Ther 366:169-183

Lancina 3rd, Michael G; Wang, Juan; Williamson, Geoffrey S et al. (2018) DenTimol as A Dendrimeric Timolol Analogue for Glaucoma Therapy: Synthesis and Preliminary Efficacy and Safety Assessment. Mol Pharm 15:2883-2889

Ginder, Gordon D; Williams Jr, David C (2018) Readers of DNA methylation, the MBD family as potential therapeutic targets. Pharmacol Ther 184:98-111

Karandashova, Sophia; Kummarapurugu, Apparao B; Zheng, Shuo et al. (2018) Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase. Am J Physiol Lung Cell Mol Physiol 314:L206-L214

Vascak, Michal; Jin, Xiaotao; Jacobs, Kimberle M et al. (2018) Mild Traumatic Brain Injury Induces Structural and Functional Disconnection of Local Neocortical Inhibitory Networks via Parvalbumin Interneuron Diffuse Axonal Injury. Cereb Cortex 28:1625-1644

Chernoukhov, A; Hussein, A; Nkurunziza, S et al. (2018) Bayesian inference in time-varying additive hazards models with applications to disease mapping. Environmetrics 29:

Dai, Lu; Smith, Charles D; Foroozesh, Maryam et al. (2018) The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo. Int J Cancer 142:2153-2162

Iqbal, Emil S; Dods, Kara K; Hartman, Matthew C T (2018) Ribosomal incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase. Org Biomol Chem 16:1073-1078

Meader, Victoria Kathryn; John, Mallory G; Frias Batista, Laysa M et al. (2018) Radical Chemistry in a Femtosecond Laser Plasma: Photochemical Reduction of Ag? in Liquid Ammonia Solution. Molecules 23: