The Structural Biology Shared Resource houses an array of resources required for the determination of molecular structure and the utilization of structural information in addressing and solving research problems. The shared resource encompasses three related areas, Nuclear Magnetic Resonance (NMR), X-ray Crystallography and Molecular Modeling. The capabilities of this facility have developed with Massey Cancer Center discretionary funds during the past CCSG grant period, and funding by the CCSG as a Massey Cancer Center shared resource is now proposed. These resources have been clustered in newly created/renovated space to facilitate access and consultation with the support team. The NMR facility houses Varian Gemini 300 and Unit Plus 500 instruments, the latter specifically equipped for macromolecular investigations. The Molecular Modeling and X-ray Crystallography facilities are co-located in newly constructed space. The Molecular Modeling facility houses 13 Graphics workstations (including a Silicon Graphics Challenge system) and software/data base suites which include Svbl, Unity, Insight II Discover, Felix, Daylight, Toolkit, the Brookhaven Protein Data Bank, and the NCI 3D molecular data base providing a comprehensive collection of modeling/analysis software. X-ray crystallographic resources include a Enraf-Nonius diffractometer and Rigaku image plate detection system. These resources, which allow both small molecule and macromolecular structure determination and analysis, are complemented by a variety of training mechanisms and services to enhance access and user capability.
| Kazarian, Elizabeth; Son, HyunYoung; Sapao, Paulene et al. (2018) SPAG17 Is Required for Male Germ Cell Differentiation and Fertility. Int J Mol Sci 19: |
| Farrell, Nicholas P; Gorle, Anil K; Peterson, Erica J et al. (2018) Metalloglycomics. Met Ions Life Sci 18: |
| Ordoñez, José A; Bandyopadhyay, Dipankar; Lachos, Victor H et al. (2018) Geostatistical estimation and prediction for censored responses. Spat Stat 23:109-123 |
| Abeyawardhane, Dinendra L; Fernández, Ricardo D; Murgas, Cody J et al. (2018) Iron Redox Chemistry Promotes Antiparallel Oligomerization of ?-Synuclein. J Am Chem Soc 140:5028-5032 |
| Zhang, Yong; Liu, Hong; Li, Wei et al. (2018) Intraflagellar transporter protein 140 (IFT140), a component of IFT-A complex, is essential for male fertility and spermiogenesis in mice. Cytoskeleton (Hoboken) 75:70-84 |
| Singh, Dhirendra P; Kaur, Gagandeep; Bagam, Prathyusha et al. (2018) Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract. Arch Toxicol 92:1767-1783 |
| Lochmann, Timothy L; Floros, Konstantinos V; Naseri, Mitra et al. (2018) Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression. Clin Cancer Res 24:360-369 |
| Zhou, Liang; Zhang, Yu; Sampath, Deepak et al. (2018) Flavopiridol enhances ABT-199 sensitivity in unfavourable-risk multiple myeloma cells in vitro and in vivo. Br J Cancer 118:388-397 |
| Huang, Dian; Leslie, Kevin A; Guest, Daniel et al. (2018) High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity. Anal Chem 90:3299-3306 |
| Salman, Ali; Koparde, Vishal; Hall, Charles E et al. (2018) Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation. Front Immunol 9:2284 |
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