Abstract

The Clinical Protocol and Data Management Shared Resource (CPDMSR) provides central managementand oversight functions for coordinating, facilitating, and reporting on Cancer Center clinical trials as well assupport for quality assurance mechanisms. The CPDMSR coordinates closely with the Biostatistics SharedResource (BSR), the Protocol Review and Monitoring System (PRMS), Data and Safety Monitoring (DSM),the Cancer Research Informatics and Services (CRIS) Shared Resource, and Cancer Center Administration.CPDMSR has four components: Director Clinical Trials Office (CTO) Ten Research Teams (9 discipline-oriented and 1 geographic) Database Management.These components assist investigators through the following services: Development and management of sponsor relations (grants, contracts, compliance) Compliance with internal and external regulatory authorities (PRMS, IRB, NIH, CTEP, FDA, etc.) Communications Continuing education with regard to evolving practice and regulatory standards in clinical research Research nursing and data management oversight Protocol specific research nursing and data management Development and maintenance of databases for clinical research (a collaborative effort with theCancer Research Informatics and Services Shared Resource (CRIS), the Biostatistics SharedResource (BSR), and Administration).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016059-28
Application #
7698841
Study Section
Subcommittee G - Education (NCI)
Project Start
2008-09-03
Project End
2011-04-30
Budget Start
2008-09-03
Budget End
2009-04-30
Support Year
28
Fiscal Year
2008
Total Cost
$20,977
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Liu, Runping; Li, Xiaojiaoyang; Huang, Zhiming et al. (2018) C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice. Hepatology 67:1441-1457
Moro, Kazuki; Kawaguchi, Tsutomu; Tsuchida, Junko et al. (2018) Ceramide species are elevated in human breast cancer and are associated with less aggressiveness. Oncotarget 9:19874-19890
Talukdar, Sarmistha; Pradhan, Anjan K; Bhoopathi, Praveen et al. (2018) MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A 115:5768-5773
Luzi, Nicole M; Lyons, Charles E; Peterson, Darrell L et al. (2018) Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome. FEBS Open Bio 8:606-613
El-Rami, Fadi; Kong, Xiangzhen; Parikh, Hardik et al. (2018) Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis. Microbiology 164:173-185
Sharma, Kanika; Vu, Thien-Trang; Cook, Wade et al. (2018) p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells. Mol Oncol 12:788-798
Rahmani, Mohamed; Nkwocha, Jewel; Hawkins, Elisa et al. (2018) Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells. Cancer Res 78:3075-3086
Powell, Melissa A; Black, Raiford T; Smith, Terry L et al. (2018) Mild Fluid Percussion Injury Induces Diffuse Axonal Damage and Reactive Synaptic Plasticity in the Mouse Olfactory Bulb. Neuroscience 371:106-118
Martin, Rebecca K; Damle, Sheela R; Valentine, Yolander A et al. (2018) B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade. Cell Rep 22:1824-1834
Stockstill, Katherine; Doyle, Timothy M; Yan, Xisheng et al. (2018) Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain. J Exp Med 215:1301-1313

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