Abstract

All cancer-related clinical trials as well as all prevention and control studies are subject to initial and ongoing Cancer Center review for scientific merit and scientific progress. The Cancer Center has the authority to initiate, monitor, and terminate all such research. This authority is exercised by the Protocol Review and Monitoring System (PRMS). The PRMS serves three main functions: (1) Conduct an ongoing evaluation of the scientific merit and scientific progress of all cancer-related clinical trials and prevention and control studies at VCU. (2) Establish priorities among protocols potentially competing for patient or research resources. (3) Provide oversight of the management of the Clinical Protocol and Data Monitoring Shared Resource. In pursuit of these functions, PRMS (4) Develops Policies and Procedures for the Oversight of Clinical Research. (5) Reviews reports from investigators. (6) Reviews reports of the Monitoring Committee (MC). (7) Reviews reports from the Data Safety and Monitoring plans, that is, Independent Physician Monitors and Data and Safety Monitoring Boards (DSMB). (8) Serves as liaison with the NIH for the purposes of reporting temporary or permanent suspension of NIHfunded protocols.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016059-29
Application #
7826927
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
29
Fiscal Year
2009
Total Cost
$34,342
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Talukdar, Sarmistha; Pradhan, Anjan K; Bhoopathi, Praveen et al. (2018) MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A 115:5768-5773
Liu, Runping; Li, Xiaojiaoyang; Huang, Zhiming et al. (2018) C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice. Hepatology 67:1441-1457
Moro, Kazuki; Kawaguchi, Tsutomu; Tsuchida, Junko et al. (2018) Ceramide species are elevated in human breast cancer and are associated with less aggressiveness. Oncotarget 9:19874-19890
El-Rami, Fadi; Kong, Xiangzhen; Parikh, Hardik et al. (2018) Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis. Microbiology 164:173-185
Luzi, Nicole M; Lyons, Charles E; Peterson, Darrell L et al. (2018) Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome. FEBS Open Bio 8:606-613
Rahmani, Mohamed; Nkwocha, Jewel; Hawkins, Elisa et al. (2018) Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells. Cancer Res 78:3075-3086
Sharma, Kanika; Vu, Thien-Trang; Cook, Wade et al. (2018) p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells. Mol Oncol 12:788-798
Martin, Rebecca K; Damle, Sheela R; Valentine, Yolander A et al. (2018) B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade. Cell Rep 22:1824-1834
Powell, Melissa A; Black, Raiford T; Smith, Terry L et al. (2018) Mild Fluid Percussion Injury Induces Diffuse Axonal Damage and Reactive Synaptic Plasticity in the Mouse Olfactory Bulb. Neuroscience 371:106-118
Vrzalikova, K; Ibrahim, M; Vockerodt, M et al. (2018) S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells. Leukemia 32:214-223

Showing the most recent 10 out of 586 publications