Abstract

The Cancer Research Center of the University of North Carolina was established in 1975 to promote interdisciplinary cancer-related research. The Cancer is now a well established entity with research programs in Tumor Immunology, Tumor Virology, Cancer Cell Biology, Chemical Carcinogenesis, Drug Development, Cancer Epidermiology, Clinical Research and Cancer Control with 80 core faculty and a newly constructed 36,000 net square foot research building. In this, our third renewal application, we request: 1. Support for the Cancer Research Center senior leadership, faculty active in cancer-related research who plan, organize and implement the cancer effort at the University of North Carolina. 2. Support for selected Cancer Center staff investigators following NCI guidelines. 3. Provision of support for the administrative functions of the Center. 4. Support for continuation of the established Cancer Research Center core facilities plus one new core facility. 5. Support for recruitment of faculty members in specific areas critical to the further development of our programs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-14
Application #
3101551
Study Section
Cancer Center Support Grant Review Committee (CCS)
Project Start
1981-08-01
Project End
1989-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
14
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Becker, Silke; Wang, Haibo; Simmons, Aaron B et al. (2018) Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms. Sci Rep 8:2003
Kim, R D; Alberts, S R; Peña, C et al. (2018) Phase I dose-escalation study of copanlisib in combination with gemcitabine or cisplatin plus gemcitabine in patients with advanced cancer. Br J Cancer 118:462-470
Chiang, Yun-Chen; Park, In-Young; Terzo, Esteban A et al. (2018) SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. Cancer Res 78:3135-3146
Suzuki, Aussie; Long, Sarah K; Salmon, Edward D (2018) An optimized method for 3D fluorescence co-localization applied to human kinetochore protein architecture. Elife 7:
Mohan, Vishwa; Sullivan, Chelsea S; Guo, Jiami et al. (2018) Temporal Regulation of Dendritic Spines Through NrCAM-Semaphorin3F Receptor Signaling in Developing Cortical Pyramidal Neurons. Cereb Cortex :
Haase, Karen P; Fox, Jaime C; Byrnes, Amy E et al. (2018) Stu2 uses a 15-nm parallel coiled coil for kinetochore localization and concomitant regulation of the mitotic spindle. Mol Biol Cell 29:285-294
Nicholls, Thomas J; Nadalutti, Cristina A; Motori, Elisa et al. (2018) Topoisomerase 3? Is Required for Decatenation and Segregation of Human mtDNA. Mol Cell 69:9-23.e6
Williams, Michelle M; Lee, Linus; Werfel, Thomas et al. (2018) Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers. Cell Death Dis 9:21
Tegowski, Matthew; Baldwin, Albert (2018) Noncanonical NF-?B in Cancer. Biomedicines 6:
Zhou, Jingying; Liu, Man; Sun, Hanyong et al. (2018) Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Gut 67:931-944

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