Abstract

The goals of the Animal Histopathology Core facility are to provide users with reliable, high quality, and cost-effective histologic services and to give investigators access to a board-certified veterinary pathologist Services include preparation of paraffin sections, histochemical staining, preparation of cryostat frozen sections, consultation and training in necropsy techniques and histopathologic assays, and provision of specialized equipment for use by investigators. The Core is directed by Virginia Godfrey, DVM, Ph.D, ACVP and the Faculty Advisor is Dr. David Lee. The Animal Histopathology Core supports a large number of Center members who use the mouse as a model system. Highlights of research supported by the Core include: analysis of knockout mice lacking CDKIs p18 and p27 by Dr. Yue Xiong (Cancer Cell Biology) and discovery of WT2 tumor suppressor gene by Dr. Bemard Weissman (Cancer Genetics). Future plans for the Core include access to another veterinary pathologist through interaction with the Mutant Mouse Regional Resource Center (MMRRC) and addition of limited immunohistochemistry services.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-31
Application #
7310754
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
31
Fiscal Year
2006
Total Cost
$124,132
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Hu, Peirong; Bi, Yanmin; Ma, Hong et al. (2018) Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization. Gene Ther 25:454-472
Townsley, Loni; Yannarell, Sarah M; Huynh, Tuanh Ngoc et al. (2018) Cyclic di-AMP Acts as an Extracellular Signal That Impacts Bacillus subtilis Biofilm Formation and Plant Attachment. MBio 9:
Schulfer, Anjelique F; Battaglia, Thomas; Alvarez, Yelina et al. (2018) Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol 3:234-242
Hall, Marissa G; Mendel, Jennifer R; Noar, Seth M et al. (2018) Why smokers avoid cigarette pack risk messages: Two randomized clinical trials in the United States. Soc Sci Med 213:165-172
Cholon, Deborah M; Gentzsch, Martina (2018) Recent progress in translational cystic fibrosis research using precision medicine strategies. J Cyst Fibros 17:S52-S60
Tappata, Manaswita; Eluri, Swathi; Perjar, Irina et al. (2018) Association of mast cells with clinical, endoscopic, and histologic findings in adults with eosinophilic esophagitis. Allergy 73:2088-2092
Che, Tao; Majumdar, Susruta; Zaidi, Saheem A et al. (2018) Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell 172:55-67.e15
Cranston, Ross D; Cespedes, Michelle S; Paczuski, Pawel et al. (2018) High Baseline Anal Human Papillomavirus and Abnormal Anal Cytology in a Phase 3 Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Individuals Older Than 26 Years: ACTG 5298. Sex Transm Dis 45:266-271
DeBono, Nathan L; Robinson, Whitney R; Lund, Jennifer L et al. (2018) Race, Menopausal Hormone Therapy, and Invasive Breast Cancer in the Carolina Breast Cancer Study. J Womens Health (Larchmt) 27:377-386
Okolie, Onyinyechukwu; Irvin, David M; Bago, Juli R et al. (2018) Intra-cavity stem cell therapy inhibits tumor progression in a novel murine model of medulloblastoma surgical resection. PLoS One 13:e0198596

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