Abstract

The goals of the Animal Histopathology Core facility are to provide users with reliable, high quality, and cost-effective histologic services and to give investigators access to a board-certified veterinary pathologist Services include preparation of paraffin sections, histochemical staining, preparation of cryostat frozen sections, consultation and training in necropsy techniques and histopathologic assays, and provision of specialized equipment for use by investigators. The Core is directed by Virginia Godfrey, DVM, Ph.D, ACVP and the Faculty Advisor is Dr. David Lee. The Animal Histopathology Core supports a large number of Center members who use the mouse as a model system. Highlights of research supported by the Core include: analysis of knockout mice lacking CDKIs p18 and p27 by Dr. Yue Xiong (Cancer Cell Biology) and discovery of WT2 tumor suppressor gene by Dr. Bemard Weissman (Cancer Genetics). Future plans for the Core include access to another veterinary pathologist through interaction with the Mutant Mouse Regional Resource Center (MMRRC) and addition of limited immunohistochemistry services.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-34
Application #
7751860
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-12-01
Budget End
2009-11-30
Support Year
34
Fiscal Year
2009
Total Cost
$272,327
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Chiou, Yi-Ying; Hu, Jinchuan; Sancar, Aziz et al. (2018) RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells. J Biol Chem 293:2476-2486
Kwo, Paul; Fried, Michael W; Reddy, K Rajender et al. (2018) Daclatasvir and sofosbuvir treatment of decompensated liver disease or post-liver transplant hepatitis C virus recurrence in patients with advanced liver disease/cirrhosis in a real-world cohort. Hepatol Commun 2:354-363
Dunn, Julia L M; Kartchner, Laurel B; Gast, Karli et al. (2018) Mammalian target of rapamycin regulates a hyperresponsive state in pulmonary neutrophils late after burn injury. J Leukoc Biol 103:909-918
Kolupaev, Oleg V; Dant, Trisha A; Bommiasamy, Hemamalini et al. (2018) Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD. Blood Adv 2:2307-2319
Beckford Vera, Denis R; Smith, Christof C; Bixby, Lisa M et al. (2018) Immuno-PET imaging of tumor-infiltrating lymphocytes using zirconium-89 radiolabeled anti-CD3 antibody in immune-competent mice bearing syngeneic tumors. PLoS One 13:e0193832
McLamarrah, Tiffany A; Buster, Daniel W; Galletta, Brian J et al. (2018) An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly. J Cell Biol 217:1217-1231
Sanoff, Hanna K (2018) Best Evidence Supports Annual Surveillance for Resected Colorectal Cancer. JAMA 319:2083-2085
Liu, Lina; Wang, Yuhua; Miao, Lei et al. (2018) Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer. Mol Ther 26:45-55
Corbie-Smith, Giselle; Wynn, Mysha; Richmond, Alan et al. (2018) Stakeholder-driven, consensus development methods to design an ethical framework and guidelines for engaged research. PLoS One 13:e0199451
Dunn, Julia L M; Kartchner, Laurel B; Stepp, Wesley H et al. (2018) Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury. Am J Physiol Lung Cell Mol Physiol 314:L822-L834

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