Bioinformatics (BIONFF) Shared Resource The Lineberger Bioinformatics Shared Resource (BIONFF) is a multifaceted shared resource established to serve the ever growing computational, data and analytic needs of the LCCC. Our expertise in bioinformatics began with the genomics program, particularly gene expression microarray analysis. The growing need for analysis, large data set management and storage, and integration with clinical and population characteristics necessitated a Lineberger-wide approach. This resulted in the creation of the UNC Lineberger Bioinformatics Shared Resource and its successful review five years ago. The continued explosion of genomics, proteomic and other clinical and population data in cancer research spurred an ever greater emphasis on integration of laboratory and clinical systems to facilitate high impact translational research. Fulfillment of this need required a growing UNC Lineberger investment in computational infrastructure, software, personnel, and systems developments. BIONF leveraged this investment toward a common infrastructure that now supports many other Lineberger Shared Resources, research programs, and individual labs. This development included a common computational infrastructure (i.e. Lineberger Data Warehouse) to integrate multiple distinct data sources, scalable software and system development, and increased analytic capacity. As data storage and analytical needs grow, the BIONF has identified specific areas of growth and development for the next 5 years for the LCCC members to continue to perform as a national and international leader in basic biology, computational genomics, translational, population and clinical research. Substantial high impact research highlights resulted from this shared resource. The most easily identified were the multi-level analysis for TCGA publications but this Shared Resource touched virtually every Center program and research effort with data intensive needs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-44
Application #
9834855
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
44
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Ghosh, Arunava; Coakley, Raymond C; Mascenik, Teresa et al. (2018) Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome. Am J Respir Crit Care Med 198:67-76
Gourevitch, Rebecca A; Rose, Sherri; Crockett, Seth D et al. (2018) Variation in Pathologist Classification of Colorectal Adenomas and Serrated Polyps. Am J Gastroenterol 113:431-439
Park, Eliza M; Deal, Allison M; Yopp, Justin M et al. (2018) Understanding health-related quality of life in adult women with metastatic cancer who have dependent children. Cancer 124:2629-2636
Kasoji, Sandeep K; Rivera, Judith N; Gessner, Ryan C et al. (2018) Early Assessment of Tumor Response to Radiation Therapy using High-Resolution Quantitative Microvascular Ultrasound Imaging. Theranostics 8:156-168
Klein, Brianna J; Krajewski, Krzysztof; Restrepo, Susana et al. (2018) Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers. Epigenetics 13:683-692
Brewer, Noel T; Hall, Marissa G; Noar, Seth M (2018) Pictorial cigarette pack warnings increase quitting: a comment on Kok et al. Health Psychol Rev 12:129-132
Birken, Sarah A; Rohweder, Catherine L; Powell, Byron J et al. (2018) T-CaST: an implementation theory comparison and selection tool. Implement Sci 13:143
Harrison, Emily B; Azam, Salma H; Pecot, Chad V (2018) Targeting Accessories to the Crime: Nanoparticle Nucleic Acid Delivery to the Tumor Microenvironment. Front Pharmacol 9:307
Keith, Benjamin P; Barrow, Jasmine B; Toyonaga, Takahiko et al. (2018) Colonic epithelial miR-31 associates with the development of Crohn's phenotypes. JCI Insight 3:
Cheng, Ning; Watkins-Schulz, Rebekah; Junkins, Robert D et al. (2018) A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer. JCI Insight 3:

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