MOLECULAR THERAPEUTICS PROGRAM The Molecular Therapeutics (MT) program is dedicated to evaluating cancer targets, developing novel therapies, and devising more effective delivery systems via highly integrated basic science and translational activities. The Program is led by Stephen Frye, Director of the Center for Integrative Chemical Biology and Drug Discovery (CICBDD) and Fred Eshelman Distinguished Professor, and Gary Johnson, Kenan Distinguished Professor in the Department of Pharmacology. The MT Program consists of 42 members who are associated with four schools and 16 departments. During the last funding period, program members have published 675 cancer-related articles. MT is highly collaborative. 16% of these papers are intra-programmatic and 33% are inter-programmatic (43% collaborative). In 2019, our program members held grants totaling $20.9M (direct cost) in cancer-relevant extramural funding, including $6.4M (direct costs) from the NCI and $13.0M other peer funding. The MT program is comprised of investigators with expertise in five broad areas: Chemical and Structural Biology; Drug Discovery and Development; Drug Delivery and Nanotechnology; Systems Pharmacology; and Oncogenic Signaling. Many investigators in the program have active collaborations with other LCCC programs, using and providing direction for LCCC's shared resources. These interactions enable many of the scientific steps needed for the discovery and development of promising therapies. In 2015, MT was rated ?outstanding? stating ?the minor weakness of this program is that, relatively few of the promising therapeutics have moved into investigator initiated clinical trials at the LCCC.? Since this review, multiple clinical studies have been initiated at UNC and other institutions based on discoveries in MT, as outlined in our response to the prior critique. Future plans build on unique translational resources available due to the creation of the Eshelman Institute for Innovation and Pinnacle Hill, which bring more than $100 million to progress UNC-based discoveries into patients. Cellular and biologic therapies will be an area of future focus for MT members enabled by the expansion of the Clinical Immunotherapy Program's GMP facility. Through these efforts, MT will continue to accelerate discovery of new cancer therapeutics and, with the Clinical Research and Breast Cancer Programs, design and execute translational and therapeutic trials in our patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-45
Application #
10089813
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-06-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Mayer, Deborah K; Landucci, Gina; Awoyinka, Lola et al. (2018) SurvivorCHESS to increase physical activity in colon cancer survivors: can we get them moving? J Cancer Surviv 12:82-94
Huo, Dezheng; Perou, Charles M; Olopade, Olufunmilayo I (2018) Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening-Reply. JAMA Oncol 4:883-884
Howe, Chanelle J; Robinson, Whitney R (2018) Survival-related Selection Bias in Studies of Racial Health Disparities: The Importance of the Target Population and Study Design. Epidemiology 29:521-524
Byrne, James D; Yeh, Jen Jen; DeSimone, Joseph M (2018) Use of iontophoresis for the treatment of cancer. J Control Release 284:144-151
Wilkin, Timothy J; Chen, Huichao; Cespedes, Michelle S et al. (2018) A Randomized, Placebo-Controlled Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Adults Aged 27 Years or Older: AIDS Clinical Trials Group Protocol A5298. Clin Infect Dis 67:1339-1346
Siegel, Marni B; He, Xiaping; Hoadley, Katherine A et al. (2018) Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer. J Clin Invest 128:1371-1383
Ubil, Eric; Caskey, Laura; Holtzhausen, Alisha et al. (2018) Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest 128:2356-2369
Hamad, Ahmad; Iweala, Onyinye I; Henderson, Cory et al. (2018) Recurrent anaphylaxis during cardiac catheterization due to ethylene oxide. J Allergy Clin Immunol Pract 6:2148-2150
Ho, G-T; Aird, R E; Liu, B et al. (2018) MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation. Mucosal Immunol 11:120-130
Pearce, Oliver M T; Delaine-Smith, Robin M; Maniati, Eleni et al. (2018) Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers. Cancer Discov 8:304-319

Showing the most recent 10 out of 1525 publications