COMMUNITY OUTREACH AND ENGAGEMENT The UNC Lineberger Comprehensive Cancer Center (LCCC) has a long history of serving the state of North Carolina (NC) through clinical care, research, policy, and cancer-focused outreach and community engagement. Since receiving NCI cancer center designation in 1975 and comprehensive status in 1990, LCCC has served as the only public comprehensive cancer center in NC with patients, outreach, and research efforts in all 100 NC counties. Based on its history of conducting impactful research and delivering cancer care to patients from all 100 NC counties, LCCC defined its catchment area a decade ago as the entire state of NC. The state has the 9th largest population in the US. and is highly diverse with regard to race, ethnicity, and rurality, with 29.3% of the NC population reporting minority race, 9.6% Hispanic ethnicity, and 54% of NC counties considered rural, with 21% of the population living in a rural county. Racially/ethnically diverse and rural populations in NC face a disproportionate burden of cancer and are key constituent populations for LCCC efforts. Notably, LCCC and its clinical venue, UNC Hospitals, have been directly responsible to the people and legislature of NC for ensuring that high quality, accessible cancer care is provided to NC residents regardless of their ability to pay; in a state without Medicaid expansion, this is an important responsibility. For decades, LCCC-supported research and outreach efforts have been committed to defining and implementing cancer practice and policies that are evidence-based and designed to address specific needs in the catchment area, particularly in racial/ethnic minority and rural populations. These responsibilities are now coordinated by the LCCC Community Outreach and Engagement (COE) Office, whose mission it is to meaningfully engage the community in cancer research, clinical care and programmatic and policy efforts to understand and serve the population's needs. COE?s vision and objective are to develop and sustain active community partnerships to reduce the burden of cancer and eliminate cancer disparities in NC and beyond.
The specific aims of the COE Office are to: (1) monitor the cancer burden and identify cancer health disparities in NC; (2) synergize institutional and community efforts to engage diverse stakeholders in addressing the cancer burden and reducing cancer health disparities in NC; (3) coordinate and amplify cancer outreach and supportive care with diverse stakeholder audiences; and (4) facilitate impactful and equity-focused cancer research in NC and beyond. The COE Office ensures that LCCC research, clinical care, and programmatic outreach efforts are timely, relevant, responsive, and infused with community perspectives, including policy makers, community providers and public health practitioners, cancer patients and caregivers, and the public at large. The impact of the work is expected to reduce cancer morbidity and mortality in NC and beyond.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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University of North Carolina Chapel Hill
Chapel Hill
United States
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Mayer, Deborah K; Landucci, Gina; Awoyinka, Lola et al. (2018) SurvivorCHESS to increase physical activity in colon cancer survivors: can we get them moving? J Cancer Surviv 12:82-94
Huo, Dezheng; Perou, Charles M; Olopade, Olufunmilayo I (2018) Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening-Reply. JAMA Oncol 4:883-884
Howe, Chanelle J; Robinson, Whitney R (2018) Survival-related Selection Bias in Studies of Racial Health Disparities: The Importance of the Target Population and Study Design. Epidemiology 29:521-524
Byrne, James D; Yeh, Jen Jen; DeSimone, Joseph M (2018) Use of iontophoresis for the treatment of cancer. J Control Release 284:144-151
Wilkin, Timothy J; Chen, Huichao; Cespedes, Michelle S et al. (2018) A Randomized, Placebo-Controlled Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Adults Aged 27 Years or Older: AIDS Clinical Trials Group Protocol A5298. Clin Infect Dis 67:1339-1346
Siegel, Marni B; He, Xiaping; Hoadley, Katherine A et al. (2018) Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer. J Clin Invest 128:1371-1383
Ubil, Eric; Caskey, Laura; Holtzhausen, Alisha et al. (2018) Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest 128:2356-2369
Hamad, Ahmad; Iweala, Onyinye I; Henderson, Cory et al. (2018) Recurrent anaphylaxis during cardiac catheterization due to ethylene oxide. J Allergy Clin Immunol Pract 6:2148-2150
Ho, G-T; Aird, R E; Liu, B et al. (2018) MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation. Mucosal Immunol 11:120-130
Pearce, Oliver M T; Delaine-Smith, Robin M; Maniati, Eleni et al. (2018) Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers. Cancer Discov 8:304-319

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