ANIMAL MODELS SHARED RESOURCE The Animal Models (AM) SR has a long and productive history providing experimental assistance to Cancer Center members. The Genetically engineered mouse models (GEMMs), Cell-line Derived Syngeneic or Xenografts (CDX) models and Patient Derived Xenografts (PDX) models are central to LCCC basic and translational research. This is an endeavor that the LCCC and UNC helped to create through the work of the late Oliver Smithies who won the Nobel Prize for his groundbreaking techniques to allow creation of gene modified mouse models. The AM SR has grown dramatically in scope and usage over the last 20 years and is now composed of services for the creation, investigation at multiple levels and imaging of animal models of cancer. These services include: innovative methods for transgenic/knockout allele production and design, generation of PDX models from primary human tumors, allele phenotyping and colony management, animal imaging and tumorigenicity studies in CDXs (both syngeneic immunocompetent and immunocompromised models), PDXs and GEMMs. The AM SR assists Cancer Center members in the planning and execution of carefully designed animal studies. The availability of this SR and its highly skilled personnel eliminates the need for Cancer Center investigators to hire similar individuals within their laboratories and ensures a high level of rigor and reproducibility for their experiments. The three arms of this SR facility; 1) GEMM production, 2) surgery on and experimental testing of syngeneic mouse, CDX and PDX mouse models, 3) translational cancer imaging, benefit from a team of three experienced Facility Directors and well-trained staff. Users of this SR benefit from significant cost reduction and decreased completion times for their studies. The AM SR requests $235,252 from the CCSG to fund this facility in fiscal year 2020; this represents approximately 6% of the total FY19 operating costs for the AM SR which was used by over 100 labs 74% of whom were LCCC members.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-45
Application #
10089826
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-06-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Mayer, Deborah K; Landucci, Gina; Awoyinka, Lola et al. (2018) SurvivorCHESS to increase physical activity in colon cancer survivors: can we get them moving? J Cancer Surviv 12:82-94
Huo, Dezheng; Perou, Charles M; Olopade, Olufunmilayo I (2018) Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening-Reply. JAMA Oncol 4:883-884
Howe, Chanelle J; Robinson, Whitney R (2018) Survival-related Selection Bias in Studies of Racial Health Disparities: The Importance of the Target Population and Study Design. Epidemiology 29:521-524
Byrne, James D; Yeh, Jen Jen; DeSimone, Joseph M (2018) Use of iontophoresis for the treatment of cancer. J Control Release 284:144-151
Wilkin, Timothy J; Chen, Huichao; Cespedes, Michelle S et al. (2018) A Randomized, Placebo-Controlled Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Adults Aged 27 Years or Older: AIDS Clinical Trials Group Protocol A5298. Clin Infect Dis 67:1339-1346
Siegel, Marni B; He, Xiaping; Hoadley, Katherine A et al. (2018) Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer. J Clin Invest 128:1371-1383
Ubil, Eric; Caskey, Laura; Holtzhausen, Alisha et al. (2018) Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest 128:2356-2369
Hamad, Ahmad; Iweala, Onyinye I; Henderson, Cory et al. (2018) Recurrent anaphylaxis during cardiac catheterization due to ethylene oxide. J Allergy Clin Immunol Pract 6:2148-2150
Ho, G-T; Aird, R E; Liu, B et al. (2018) MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation. Mucosal Immunol 11:120-130
Pearce, Oliver M T; Delaine-Smith, Robin M; Maniati, Eleni et al. (2018) Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers. Cancer Discov 8:304-319

Showing the most recent 10 out of 1525 publications