COMMUNICATIONS FOR HEALTH APPLICATIONS AND INTERVENTIONS The Communications for Health Applications and Interventions (CHAI) SR provides tremendous value and service to the Center through its development of modern communication techniques for the range of implementation, clinical, prevention and control research. The services available include behavioral e- and m- health interventions, qualitative and software design services using adaptive technology. Services for faculty research projects include: responsive web application, device integration, geofencing, user experience (UX) and qualitative survey development. The SR was used by more than 30 faculty in fiscal year 2019 which represented 82% of the total users. CHAI requests $139,365 of a total operating budget of $959,660. The Center ensure cost-effectiveness and value to the membership through a sustained annual contribution of approximately $310,000. It is well integrated within the LCCC programs contributed to key studies including: ? PRO-PM: a qualitative study designed to understand patient, caregiver and provider perceptions on patient reported outcomes during chemotherapy. CHAI supported the research through creation of interview guides and conduct of over 100 one on one interviews with adult patients receiving chemotherapy, healthcare administrators, health service researchers, clinicians, and patient advocates across six cancer centers nationwide. ? PERC: a mixed method study to evaluate feasibility and acceptability of a web based, couple-focused intervention on prostate cancer symptom management, quality of life and psychosocial factors. CHAI hosted the web site and supported data collection though a built-in automatic tracking system for times logged in, time spent on site. ? COMET: a 5 year PCORI-funded project, will involve 1200 patients. The goal of the COMET (Comparison of Operative vs Monitoring and Endocrine Therapy) trial for low-risk ductal carcinoma in situ (DCIS). CHAI contributed to the creation of a responsive website that provide accessible, understandable, and evidence-based information about DCIS, treatment options, including the trade- offs of each treatment option. The 9 person CHAI SR includes experts in qualitative analysis, software development graphic design and project management. CHAI is directed by Deborah Tate, PhD a nationally recognized expert in communications and behavioral science. The SR uses multiple techniques to test the efficacy of e- or m- messaging and is careful to assess changes in communication usage for example that many in rural areas have restricted access to broadband yet higher penetration through mobile devices. Integration with Community Outreach and Engagement is key in the development of CHAI methods.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
McNeill, Robert S; Stroobant, Emily E; Smithberger, Erin et al. (2018) PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition. PLoS One 13:e0200014
Graham-Gurysh, Elizabeth; Moore, Kathryn M; Satterlee, Andrew B et al. (2018) Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection. Mol Pharm 15:1309-1318
Trout, Susan; Goldstein, Adam O; Marks, Lawrence et al. (2018) Treating Tobacco Use in Patients with Incurable Malignancies: Should We Even Start the Conversation? J Palliat Med 21:746-750
Lee, Clara Nan-Hi; Pignone, Michael Patrick; Deal, Allison M et al. (2018) Accuracy of Predictions of Patients With Breast Cancer of Future Well-being After Immediate Breast Reconstruction. JAMA Surg 153:e176112
Ricketts, Christopher J; De Cubas, Aguirre A; Fan, Huihui et al. (2018) The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Rep 23:313-326.e5
Golden, Shelley D; Kong, Amanda Y; Lee, Joseph G L et al. (2018) Disparities in cigarette tax exposure by race, ethnicity, poverty status and sexual orientation, 2006-2014, USA. Prev Med 108:137-144
Song, Wantong; Shen, Limei; Wang, Ying et al. (2018) Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap. Nat Commun 9:2237
Kaur, Gurpreet; Guruprasad, Kunchur; Temple, Brenda R S et al. (2018) Structural complexity and functional diversity of plant NADPH oxidases. Amino Acids 50:79-94
Moore, Patrick J; Reidel, Boris; Ghosh, Arunava et al. (2018) Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration. FASEB J :fj201800345R
Anders, Penny M; Montgomery, Nathan D; Montgomery, Stephanie A et al. (2018) Human herpesvirus-encoded kinase induces B cell lymphomas in vivo. J Clin Invest 128:2519-2534

Showing the most recent 10 out of 1525 publications