STATEWIDE CANCER DATA SHARED RESOURCE Statewide Cancer Data (SCD) is a two component SR that combines Rapid Case Ascertainment (RCA) and the Cancer Information and Population Health Resource (CIPHR). This resource reflects a commitment of the cancer center and of the CPC, CR, BC and CE Programs to support research in real-world populations with a focus on disparities and access to care ? particularly in the state of North Carolina. A strong relationship between RCA and the North Carolina Central Cancer Registry (CCR), and the hospital tumor registrars allows RCA to facilitate population-based studies of cancer for Lineberger Cancer Center and outside investigators. For rapid case ascertainment, the Central Cancer Registry utilizes RCA personnel, and proactively requests and obtains diagnostic information within one month of the patient?s diagnosis. The other component of this resource is CIPHR, which includes cancer case data from CCR linked to healthcare administrative claims data from Medicare, Medicaid, and private insurance. The resulting claims dataset represents over 8 million individuals. Beneficiaries are reconciled across payers and linked to approximately 750,000 North Carolina cancer cases from the last decade. The size and complexity of the population-based datasets created and housed by this resource require an interdisciplinary staff to successfully and efficiently manage, analyze, and understand the data. SR staff apply diverse and innovative data management and analytic methods many specifically created for CIPHR to answer important population-based questions about the LCCC catchment area. Linkage of LCCC population-based cohorts has been accomplished. Researcher support from SCD typically extends from development of the initial research question, gathering preliminary data for grant applications through cohort discovery, statistical analysis, and manuscript writing. In FY2019, 37 LCCC members representing 93% of users used the SCD SR. This is a cost-effective mechanism to both collect cancer cases efficiently across the state and to disseminate that information. Since CIPHR began linking to Medicare data in 2012, it has been extensively used by faculty, trainees, and various collaborators both within UNC and at other cancer centers. To date, more than $15M in external funding has been enabled by this shared resource. The SCD requests $206,586 from the CCSG, which is 12% of the total FY20 $1.8 M operating budget, $900,000 of which is provided by the LCCC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-45
Application #
10089836
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-06-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Song, Wantong; Shen, Limei; Wang, Ying et al. (2018) Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap. Nat Commun 9:2237
Kaur, Gurpreet; Guruprasad, Kunchur; Temple, Brenda R S et al. (2018) Structural complexity and functional diversity of plant NADPH oxidases. Amino Acids 50:79-94
McNeill, Robert S; Stroobant, Emily E; Smithberger, Erin et al. (2018) PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition. PLoS One 13:e0200014
Graham-Gurysh, Elizabeth; Moore, Kathryn M; Satterlee, Andrew B et al. (2018) Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection. Mol Pharm 15:1309-1318
Trout, Susan; Goldstein, Adam O; Marks, Lawrence et al. (2018) Treating Tobacco Use in Patients with Incurable Malignancies: Should We Even Start the Conversation? J Palliat Med 21:746-750
Lee, Clara Nan-Hi; Pignone, Michael Patrick; Deal, Allison M et al. (2018) Accuracy of Predictions of Patients With Breast Cancer of Future Well-being After Immediate Breast Reconstruction. JAMA Surg 153:e176112
Ricketts, Christopher J; De Cubas, Aguirre A; Fan, Huihui et al. (2018) The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Rep 23:313-326.e5
Golden, Shelley D; Kong, Amanda Y; Lee, Joseph G L et al. (2018) Disparities in cigarette tax exposure by race, ethnicity, poverty status and sexual orientation, 2006-2014, USA. Prev Med 108:137-144
Morgan, Jennifer C; Southwell, Brian G; Noar, Seth M et al. (2018) Frequency and Content of Conversations About Pictorial Warnings on Cigarette Packs. Nicotine Tob Res 20:882-887
Liu, Qi; Zhu, Hongda; Liu, Yun et al. (2018) BRAF peptide vaccine facilitates therapy of murine BRAF-mutant melanoma. Cancer Immunol Immunother 67:299-310

Showing the most recent 10 out of 1525 publications