BIOSTATISTICS SHARED RESOURCE The Biostatistics Shared Resource (BIOS) provides access for LCCC faculty across the basic, clinical, translational and population science spectrum to an experienced staff and recognized national leaders in statistical modeling and analysis. The Center?s breadth of science requires a broad range of expertise available in BIOS and includes for example: population sciences, psychometric analysis, clinical trial design and analysis, basic experimental science as well as ?big data? ?omics. This range requires a core that can be accessed by virtually all members on the ?front end? for experimental design from small undertakings to large trials. Access is encouraged through a weekly walk in clinic centrally located in the Lineberger atrium where faculty and students at all levels can discuss projects at their inception. The masters and doctoral level full time BIOS SR staff operate this clinic and there is also a traditional appointment system for researchers with defined problems. This team is supported by senior biostatisticians with a wide range of expertise from the School of Public Health?s internationally recognized Biostatistics Department. These leaders also serve on the Protocol Review Committee and the Data and Safety Monitoring Committee. Senior faculty are fully engaged in LCCC research as collaborators and researchers in methods, for example in the Biostatistics PO1 in clinical trials methods development. In addition both staff and faculty encourage the participation of graduate students who have the opportunity to engage faculty and peers in statistical review as part of their own training under the guidance of the senior faculty-level statisticians. This facility is a LCCC exclusive SR and was well used by over 100 faculty in fiscal year 2019. BIOS requests $239,374 which is approximately 20% of the total operating costs for this highly subsidized facility sustained by an annual LCCC contribution of ~$1M BIOS has been a key partner in multiple grants and publications over the prior five years, from Dr Rashid?s analysis of Nobel Laureate Aziz Sancar?s work on circadian timing of DNA repair processes to Dr Tan?s design for Dr Song?s project in caregiver?s management of patient symptoms.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-45
Application #
10089837
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-06-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zhang, Yugen; Dittmer, Dirk P; Mieczkowski, Piotr A et al. (2018) RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner. MBio 9:
Abida, Wassim; Sawyers, Charles L (2018) Targeting DNA Repair in Prostate Cancer. J Clin Oncol 36:1017-1019
Bigi, Rachele; Landis, Justin T; An, Hyowon et al. (2018) Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A 115:E11379-E11387
Liu, Jianfang; Lichtenberg, Tara; Hoadley, Katherine A et al. (2018) An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics. Cell 173:400-416.e11
Song, Lixin; Dunlap, Kaitlyn L; Tan, Xianming et al. (2018) Enhancing Survivorship Care Planning for Patients With Localized Prostate Cancer Using a Couple-Focused mHealth Symptom Self-Management Program: Protocol for a Feasibility Study. JMIR Res Protoc 7:e51
Guseman, Alex J; Perez Goncalves, Gerardo M; Speer, Shannon L et al. (2018) Protein shape modulates crowding effects. Proc Natl Acad Sci U S A 115:10965-10970
Xu, Bowen; Cai, Ling; Butler, Jason M et al. (2018) The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports 10:675-683
Gartlan, Kate H; Bommiasamy, Hemamalini; Paz, Katelyn et al. (2018) A critical role for donor-derived IL-22 in cutaneous chronic GVHD. Am J Transplant 18:810-820
Lee, Andrew L; Sapienza, Paul J (2018) Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase. Front Mol Biosci 5:47
Parada Jr, Humberto; Hall, Marissa G; Boynton, Marcella H et al. (2018) Trajectories of Responses to Pictorial Cigarette Pack Warnings. Nicotine Tob Res 20:876-881

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