The NYU Cancer Institute (NYUCI), previously known as the Rita J. and Stanley H. Kaplan Comprehensive Cancer Center (KCCC), is a university based matrix organization, located principally on the main campus of the NYU Medical Center in mid-town Manhattan. In the last three years, the NYUCI has received greatly increased support from its parent organizations, the NYU School of Medicine and the NYU Hospitals Center and has gone through intensive strategic planning to achieve its present integration of basic, translational, clinical, and population science. With this expansion of its role, the KCCC was accorded """"""""Institute"""""""" status. Five formal Basic Science Programs are presented. Three of these, Environmental & Molecular Carcinogenesis, Growth Control & Tumor Immunology, have been included in prior CCSG application; however, each has added new areas to complement previous strengths and, in the case of the latter two, are either being led by or have added new members who have revitalized the Programs. Cancer Neurobiology and Stem Cell Biology represent the culmination of new initiatives resulting from the bringing together new members of the NYUCI into collaborations with senior scientists of the NYU School of Medicine and its Skirball Institute of Biomolecular Medicine. One additional Basic Science Program, in the area of Endothelial Research, is in development. Two multi-disciplinary, Disease-Oriented Programs, in Breast & Genitourinary Cancer, represent our emphasis on therapeutic and translational research. Four others, Neuro-oncology, Gynecologic Oncology, Gastrointestinal Oncology & Cutaneous Malignancies, are in development. Finally, one Population Science Program, Molecular Epidemiology & Prevention, demonstrates a broad range of interests in the identification of cancer risk factors and the translation of such knowledge into preventive and clinical interventions at the population level. In addition, nine Shared Resources are presented, with two others in development. Developmental funds for pilot studies, recruitment of new investigators and the establishment of new shared resources are also requested.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016087-26
Application #
7023913
Study Section
Subcommittee G - Education (NCI)
Program Officer
Silkensen, Shannon M
Project Start
1975-06-30
Project End
2008-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
26
Fiscal Year
2006
Total Cost
$2,639,993
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Lee, Hyun-Wook; Park, Sung-Hyun; Weng, Mao-Wen et al. (2018) E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proc Natl Acad Sci U S A 115:E1560-E1569
Evensen, Nikki A; Madhusoodhan, P Pallavi; Meyer, Julia et al. (2018) MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia. Haematologica 103:830-839
Formenti, Silvia C; Rudqvist, Nils-Petter; Golden, Encouse et al. (2018) Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nat Med 24:1845-1851
Sun, Qi; Rabbani, Piul; Takeo, Makoto et al. (2018) Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing. J Invest Dermatol 138:1591-1600
Gagner, Jean-Pierre; Zagzag, David (2018) Probing Glioblastoma Tissue Heterogeneity with Laser Capture Microdissection. Methods Mol Biol 1741:209-220
Xu, Yang; Taylor, Paul; Andrade, Joshua et al. (2018) Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma. Cancer Res 78:6539-6548
Martin, Patricia K; Marchiando, Amanda; Xu, Ruliang et al. (2018) Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota. Nat Microbiol 3:1131-1141
Tsay, Jun-Chieh J; Wu, Benjamin G; Badri, Michelle H et al. (2018) Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer. Am J Respir Crit Care Med 198:1188-1198
Coux, Rémi-Xavier; Teixeira, Felipe Karam; Lehmann, Ruth (2018) L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary. Development 145:
de la Parra, Columba; Ernlund, Amanda; Alard, Amandine et al. (2018) A widespread alternate form of cap-dependent mRNA translation initiation. Nat Commun 9:3068

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