The long-term mission of the Genome Technology Center (GTC) is to enable and foster institutional science by providing advanced expertise in genomics, centralized state-of-the-art resources, and the training necessary to promote cutting-edge basic, clinical and translational cancer research through dedicated collaborative effort. GTC provides a modern environment that facilitates cross-talk between researchers from diverse fields such as biology, development, clinical research, chemistry and bioinformatics. GTC maintains and provides affordable access to technologically advanced instrumentation including multiple platforms for massively parallel sequencing and microarray profiling, and it creates an educational environment to instruct faculty, staff, fellows, and students on how these technologies can positively advance their research, prepare successful grant applications and publish highly competitive results. GTC also directly assists investigators with the presentation and successful publication of their data. To achieve the specific aims and all aspects of the investigator's cancer-oriented projects, GTC frequently and actively collaborates with additional NYUCI shared resources including the BioRepository Center, Experimental Pathology and the Biomedical Informatics Shared Resource.
The relevance of the Genome Technology Center to the public health lies in its significant contribution to general understanding of molecular mechanisms underlying human malignancies and to the future development of successful therapeutic approaches against human cancers. To that end, the GTC assists over 120 NYULMC laboratories to advance their basic, clinical and translational research.
|Formenti, Silvia C; Lee, Percy; Adams, Sylvia et al. (2018) Focal Irradiation and Systemic TGF? Blockade in Metastatic Breast Cancer. Clin Cancer Res 24:2493-2504|
|Snuderl, Matija; Kannan, Kasthuri; Pfaff, Elke et al. (2018) Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. Nat Commun 9:2868|
|Stafford, James M; Lee, Chul-Hwan; Voigt, Philipp et al. (2018) Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Sci Adv 4:eaau5935|
|Lee, Chul-Hwan; Yu, Jia-Ray; Kumar, Sunil et al. (2018) Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin. Mol Cell 70:422-434.e6|
|Aiello, Nicole M; Maddipati, Ravikanth; Norgard, Robert J et al. (2018) EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Dev Cell 45:681-695.e4|
|Jung, Heekyung; Baek, Myungin; D'Elia, Kristen P et al. (2018) The Ancient Origins of Neural Substrates for Land Walking. Cell 172:667-682.e15|
|Herline, Krystal; Prelli, Frances; Mehta, Pankaj et al. (2018) Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model. Alzheimers Res Ther 10:54|
|Xu, Mo; Pokrovskii, Maria; Ding, Yi et al. (2018) c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature 554:373-377|
|Snetkova, Valentina; Skok, Jane A (2018) Enhancer talk. Epigenomics 10:483-498|
|Litwinoff, Evelyn M S; Gold, Merav Y; Singh, Karan et al. (2018) Myeloid ATG16L1 does not affect adipose tissue inflammation or body mass in mice fed high fat diet. Obes Res Clin Pract 12:174-186|
Showing the most recent 10 out of 1170 publications