GENOME TECHNOLOGY CENTER (GTC) The Genome Technology Center (GTC) shared resource provides centralized, expert genomic services to all Perlmutter Cancer Center (PCC) investigators at NYU Langone Health (NYULH). Under the direction of Dr. Adriana Heguy, a recognized expert in genomic analysis, GTC is a state-of-the-art, high throughput, fast turnaround, fully equipped genomic facility, specializing in both short-read (Illumina) and long-read (PacBio, Oxford Nanopore Technologies) deep sequencing and sample preparation for a variety of applications including RNASeq, ChIPSeq, ATACSeq, bisulfite sequencing, single cell sequencing, chromatin conformation sequencing approaches, and many others. The GTC mission is to foster cross-institutional science by providing highly specialized support in a collaborative environment that results in successful grant applications and publications. GTC provides affordable access to technologically advanced services and instrumentation, and an educational environment for faculty, staff, fellows, and students in the PCC who are interested in learning how these technologies can advance their basic and clinical cancer research.
The Specific Aims of GTC are:
Aim 1) To provide expert genomic services;
Aim 2) To evaluate and implement novel genomic technology and thereby maintain state-of-the-art services;
Aim 3) To facilitate data sharing and storage through high performance computing secure servers;
Aim 4) To assist the CLIA-certified NGS laboratory in technology development and validation;
Aim 5) To educate and inform members of the PCC communities on genomic technologies and their utility for cancer research.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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New York University
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Wang, Shiyang; Liechty, Benjamin; Patel, Seema et al. (2018) Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosis type 1 and 2 associated tumors. J Neurooncol 138:183-190
Nancy, Patrice; Siewiera, Johan; Rizzuto, Gabrielle et al. (2018) H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition. J Clin Invest 128:233-247
Schulfer, Anjelique F; Battaglia, Thomas; Alvarez, Yelina et al. (2018) Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol 3:234-242
Ge, Wenzhen; Clendenen, Tess V; Afanasyeva, Yelena et al. (2018) Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts. Int J Cancer 142:2215-2226
Ruggles, Kelly V; Wang, Jincheng; Volkova, Angelina et al. (2018) Changes in the Gut Microbiota of Urban Subjects during an Immersion in the Traditional Diet and Lifestyle of a Rainforest Village. mSphere 3:
Winer, Benjamin Y; Shirvani-Dastgerdi, Elham; Bram, Yaron et al. (2018) Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med 10:
Gupta, Ankit; Xu, Jing; Lee, Shirley et al. (2018) Facile target validation in an animal model with intracellularly expressed monobodies. Nat Chem Biol 14:895-900
Marié, Isabelle J; Chang, Hao-Ming; Levy, David E (2018) HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies. J Exp Med 215:3194-3212
Evensen, Nikki A; Madhusoodhan, P Pallavi; Meyer, Julia et al. (2018) MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia. Haematologica 103:830-839
Lee, Hyun-Wook; Park, Sung-Hyun; Weng, Mao-Wen et al. (2018) E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proc Natl Acad Sci U S A 115:E1560-E1569

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