Abstract

Microscopy (MICROS) The Microscopy Core Lab Shared Resource (MICROS) is a new Shared Resource that provides state-of-the-art, comprehensive light and electron microscopy imaging to PCC investigators. Under the expert direction of Dr. Feng-Xia (Alice) Liang, the mission of MICROS is to bring imaging and image analysis tools, ranging from angstroms to centimeters, to PCC members regardless of their pre-existing expertise, and to provide assistance at every stage from experimental design through execution and analysis to final presentation. MICROS staff learn from PCC members what are the scientific questions they hope to address through imaging and advise them about imaging technologies. When needed, MICROS staff develop new protocols, including those that integrate with other PCC shared resources, especially Experimental Pathology and Applied Bioinformatics Laboratory. In addition, as an imaging hub, MICROS serves as an initiator of collaboration among PCC investigators by means of three Specific Aims:
Aim 1) To provide PCC members with cutting edge imaging technologies;
Aim 2) To determine the best imaging techniques to address the specific scientific questions of PCC investigators;
Aim 3) To maintain PCC light microscopes and provide expertise needed to catalyze PCC collaboration with the newly established cryoEM services.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016087-39
Application #
9867639
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-03-01
Budget End
2021-02-28
Support Year
39
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Gong, Yixiao; Lazaris, Charalampos; Sakellaropoulos, Theodore et al. (2018) Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries. Nat Commun 9:542
Kirkling, Margaret E; Cytlak, Urszula; Lau, Colleen M et al. (2018) Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells. Cell Rep 23:3658-3672.e6
Minton, Denise R; Nam, Minwoo; McLaughlin, Daniel J et al. (2018) Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Mol Cell 69:610-621.e5
Hadi, Tarik; Boytard, Ludovic; Silvestro, Michele et al. (2018) Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. Nat Commun 9:5022
Zhang, Yilong; Shao, Yongzhao (2018) Concordance measure and discriminatory accuracy in transformation cure models. Biostatistics 19:14-26
Lim, Chae Ho; Sun, Qi; Ratti, Karan et al. (2018) Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. Nat Commun 9:4903
Peled, Michael; Tocheva, Anna S; Sandigursky, Sabina et al. (2018) Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor. Proc Natl Acad Sci U S A 115:E468-E477
Kistler, Kathryn E; Trcek, Tatjana; Hurd, Thomas R et al. (2018) Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells. Elife 7:
Puranik, Amrutesh S; Leaf, Irina A; Jensen, Mark A et al. (2018) Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney. Sci Rep 8:13948
Saint Fleur-Lominy, Shella; Maus, Mate; Vaeth, Martin et al. (2018) STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia. Cell Rep 24:3045-3060.e5

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