PRECISION IMMUNOLOGY LABORATORY SHARED RESOURCE (PIL) The Precision Immunology Laboratory Shared Resource (PIL) is a highly restructured PCC Shared Resource designed to comprehensively study immune cell phenotype and function. The mission of PIL is to characterize and understand anti-tumor immune responses, determine mechanisms by which immune escape and evasion occur, and predict patient responses to cancer immunotherapy, in support of Perlmutter Cancer Center (PCC) investigators. Under the direction of world-recognized immune monitoring expert Dr. Pratip Chattopadhyay, formerly of the NIH Vaccine Center, PIL offers a wide range of services for immune monitoring, including high quality cell processing and immunoassays for PCC clinical trials, with rigorous quality control and bioinformatics capabilities to interpret the results. PIL also provides a wide range of flow cytometry services (including education) for basic, population and clinical researchers at PCC, and applies cutting-edge technology for high parameter, single cell immune analysis, that provides results that are robust, accessible, and interpretable by researchers and clinicians.
The Specific Aims of PIL are:
Aim 1) To provide high-quality cell processing and immunoassays for PCC clinical trials with vigorous quality control and bioinformatics capabilities;
Aim 2) To provide a wide range of flow cytometry services, including education;
Aim 3) To develop and apply cutting-edge technology for high parameter, single cell immune analysis providing robust results no generally available elsewhere.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
New York
United States
Zip Code
Pelzek, Adam J; Shopsin, Bo; Radke, Emily E et al. (2018) Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection. MBio 9:
Chiou, Kenneth L; Bergey, Christina M (2018) Methylation-based enrichment facilitates low-cost, noninvasive genomic scale sequencing of populations from feces. Sci Rep 8:1975
Jose, Cynthia C; Jagannathan, Lakshmanan; Tanwar, Vinay S et al. (2018) Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1. Mol Carcinog 57:794-806
Kourtis, Nikos; Lazaris, Charalampos; Hockemeyer, Kathryn et al. (2018) Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia. Nat Med 24:1157-1166
Formenti, Silvia C; Lee, Percy; Adams, Sylvia et al. (2018) Focal Irradiation and Systemic TGF? Blockade in Metastatic Breast Cancer. Clin Cancer Res 24:2493-2504
Snuderl, Matija; Kannan, Kasthuri; Pfaff, Elke et al. (2018) Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. Nat Commun 9:2868
Lee, Chul-Hwan; Yu, Jia-Ray; Kumar, Sunil et al. (2018) Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin. Mol Cell 70:422-434.e6
Stafford, James M; Lee, Chul-Hwan; Voigt, Philipp et al. (2018) Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Sci Adv 4:eaau5935
Jung, Heekyung; Baek, Myungin; D'Elia, Kristen P et al. (2018) The Ancient Origins of Neural Substrates for Land Walking. Cell 172:667-682.e15
Aiello, Nicole M; Maddipati, Ravikanth; Norgard, Robert J et al. (2018) EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Dev Cell 45:681-695.e4

Showing the most recent 10 out of 1170 publications