The vision of the Epidemiology and Cancer Control Program (ECC) is to reduce the cancer burden in the PCC catchment area and beyond. To achieve this vision, we aim to conduct innovative and high impact research, discovering risk factors and translating this knowledge into effective cancer control. Under the dynamic new leadership of Jiyoung Ahn and Donna Shelley, ECC organizes its research efforts into four complementary thematic aims:
Aim1 : to discover and effectively control cancer-causing microbial risk factors;
Aim 2 : to assess and effectively control environmental and behavioral risk factors;
Aim 3 : to improve early detection and risk prediction for high-risk individuals;
and Aim 4 : to optimize cancer care delivery to patients through health services research. The Program is composed of 33 members and 11 associate members from 12 academic departments in the NYU School of Medicine (NYUSoM), particularly our new Department of Population Health, as well as the NYU College of Nursing, College of Dentistry, and the new College of Global Public Health. ECC members currently have 60 funded projects totaling $10.5M in annual direct costs, $2.7M from NCI (39% of peer-reviewed funding). Our members are highly collaborative, as indicated by 21% intra- and 33% inter- programmatic collaborations, 33% inter-institutional collaborations (with other NCI-CCs), and 22 multi-PI grants. Program members published 686 papers in the current period, including many in top tier journals, such as NEJM, Lancet, and JAMA Pediatrics (15% of publications [n=102] have IF>10). Our signature research on the microbiome has led to novel discoveries of cancer-causing microbial risk factors, published in JAMA Oncology, Gut, JNCI and already cited more than 250 times; these paradigm-shifting hypotheses on microbial contribution to these malignancies have also fueled translation to clinical trials and new avenues of basic science research. Our work on developing innovative smoking control methods and assessing air pollution? cancer risk relationships impacted major health policy locally in our catchment area and nationally. Our health services research, including studies of optimized imaging use and active surveillance, helped inform standard guidelines of care for prostate cancer patients. ECC has continued to make exceptionally high impact scientific contributions, with particular attention to the needs of our unique catchment area.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016087-40
Application #
10124330
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-12-01
Project End
2024-02-29
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
40
Fiscal Year
2021
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Wang, Shiyang; Liechty, Benjamin; Patel, Seema et al. (2018) Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosis type 1 and 2 associated tumors. J Neurooncol 138:183-190
Nancy, Patrice; Siewiera, Johan; Rizzuto, Gabrielle et al. (2018) H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition. J Clin Invest 128:233-247
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Evensen, Nikki A; Madhusoodhan, P Pallavi; Meyer, Julia et al. (2018) MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia. Haematologica 103:830-839
Lee, Hyun-Wook; Park, Sung-Hyun; Weng, Mao-Wen et al. (2018) E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proc Natl Acad Sci U S A 115:E1560-E1569

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