The Cancer Genetic Counseling Shared Resource (CGCSR) provides genetic counseling and testing services and high-risk sample ascertainment for researchers who wish to utilize genetic testing as part of their research studies. This Shared Resource has evolved over the past decade to meet the increasing demands of researchers utilizing genetic testing (e.g. BRCA1, BRCA2) in their research protocols. Such testing in human subjects created the need to provide accurate, responsible genetic counseling to research subjects. Our objectives include the following: a) to provide genetic counseling services to patients who undergo genetic testing as a part of a research protocol;b) to provide consultation and to serve as a content expert and collaborator to researchers who are developing protocols that will include genetic testing for cancer susceptibility genes (this includes assistance with the IRB approval process and consent forms);c) to provide researchers with access to patient populations of interest (e.g. high risk patients);d) to train graduate students in genetic counseling in the area of cancer genetics during a three month fellowship, during which time they will assist and participate in clinical research. Once trained, these genetic counselors will be able to function as cancer genetic counselors in academic medical settings. Patients are seen at our New Haven office and outreach clinics in Greenwich, Norwalk, and Danbury, CT. The CGCSR has been used by five peer-reviewed YCC members representing the Cancer Genetics and Radiobiology &Radiotherapy (R&R) Research Programs at the Yale Cancer Center. The expectation is that this Shared Resource will be more extensively used during the next project period by members of the Developmental Therapeutics and R&R Programs as the number of investigator-initiated clinical trials requiring genetic predisposition testing expands.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016359-32
Application #
8132530
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
32
Fiscal Year
2010
Total Cost
$45,577
Indirect Cost
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Bonazzoli, Elena; Predolini, Federica; Cocco, Emiliano et al. (2018) Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer. Clin Cancer Res 24:4845-4853
Villarroel-Espindola, Franz; Yu, Xiaoqing; Datar, Ila et al. (2018) Spatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non-Small Cell Lung Cancer. Clin Cancer Res 24:1562-1573
Wadia, Roxanne J; Stolar, Marilyn; Grens, Clarice et al. (2018) The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients. Oncotarget 9:7322-7331
De Feyter, Henk M; Behar, Kevin L; Corbin, Zachary A et al. (2018) Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Sci Adv 4:eaat7314
Ventura, Alessandra; Vassall, Aaron; Robinson, Eve et al. (2018) Extracorporeal Photochemotherapy Drives Monocyte-to-Dendritic Cell Maturation to Induce Anticancer Immunity. Cancer Res 78:4045-4058
Xiao, Qian; Wu, Jibo; Wang, Wei-Jia et al. (2018) DKK2 imparts tumor immunity evasion through ?-catenin-independent suppression of cytotoxic immune-cell activation. Nat Med 24:262-270
Jagannath, Sundar; Laubach, Jacob; Wong, Ellice et al. (2018) Elotuzumab monotherapy in patients with smouldering multiple myeloma: a phase 2 study. Br J Haematol 182:495-503
Liu, Xiaoni; Zhang, Shang-Min; McGeary, Meaghan K et al. (2018) KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations. Mol Cancer Ther :
Chae, Wook-Jin; Bothwell, Alfred L M (2018) Therapeutic Potential of Gene-Modified Regulatory T Cells: From Bench to Bedside. Front Immunol 9:303
Kim, Hanseul; Keum, NaNa; Giovannucci, Edward L et al. (2018) Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies. Int J Cancer 143:1047-1053

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