Cancer Prevention and Control Research Program

Irwin, Melinda L.

Abstract

CANCERPREVENTIONANDCONTROLRESEARCHPROGRAM PROGRAMCODE:CPC PROJECTSUMMARY/ABSTRACT ThemissionofCPCistopreventandcontrolcancerbyidentifyingfactorsthatcontributetocancer developmentandoutcomes,andconductinginterventionstoaddressthesefactors.
The SpecificAims ofour programareto:1)identifylifestyle,environmental,andgeneticriskfactorsintheetiologyofcancer;?2)assess thepatternsofcarereceivedbypatientswithcancertoidentifyeffectivestrategiestoimprovepatient outcomes,and3)conductandevaluatelifestylebehavioralinterventionsforcancerpreventionandcontrol. Dr.MelindaIrwinisAssociateDirectorforPopulationSciencesandco-leadstheCPCprogramalongwithDr. XiaomeiMa.Dr.Irwin?sexpertiseisinlifestylebehavioralinterventions,sosheoverseesresearchrelatedto Aim3.Dr.Ma?sexpertiseisinetiologyandoutcomes,sosheoverseesCPCresearchrelatedtoAims1and2. Together,Drs.IrwinandMafacilitatethecollaborationofCPCmemberswithmembersfromotherresearch programsanddisease-alignedresearchteams(DARTs)withthegoalofstimulatingtransdisciplinaryresearch thatwillimpactcancerriskandmortalityrateswithinandbeyondthestateofConnecticut. Currently,thereare38CPCmembers,withprimaryappointmentsin11departmentsandthreeschools.Our cancer-relatedfunding(directcostonly)hasincreased5%from$6.4Minthepreviouscycleto$6.7Minthe currentcycle,ofwhich$5.6M(84%)waspeerreviewedand$2.5MwasfromNCI.Ofthe793cancer-related publicationsbyCPCmembersfromJuly2012toJune2017(with30%and24%involvingintra-andinter- collaborations),manyhavehadamajorimpactonclinicaland/orpublichealthpractice.Drs.GrossandYu?s (RadiobiologyandRadiotherapy[RR]program)findingsofearlytoxicityfromprotonbeamtherapyforprostate cancerwascitedinthedecisionbyBlueShieldofCaliforniatostopreimbursingprotonbeamtherapyfor prostatecancer.Dr.Niccolai?sHPVvaccinationresearchhasimprovedvaccinationratesandhaslocal,state, andnationalimpact.Drs.Irwin,Sanft,Cartmel,andChagpar?swork,showingbenefitsofexerciseandweight lossoncancerbiomarkersandtreatment-relatedsideeffects,ischangingcancercaredeliverywith implementationoflifestyle/behaviorcounselingintheclinic. YCCandCPCleadershiphavedevelopedastrategicplantoguideourfutureinitiatives,withtheprimarygoal ofaddingdepthandbreadthtoourexistingstrengthsincanceroutcomesandlifestyle/behavioralresearch. Goalswithinthenextfiveyearsincluderecruitmentofadditionalfacultyincanceroutcomesanddissemination andimplementationresearch;?thesubmissionofaP01focusedonrandomizedtrialsofenergybalancein cancersurvivors;?twoT32applicationson1)obesityresearchand2)canceretiology,outcomesand survivorshipresearch;?andparticipatinginsubmissionofmoreSPOREapplicationswithCPCmembers leadingprojects.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 2P30CA016359-39
• Application #: 9570289
• Study Section: Subcommittee I - Transistion to Independence (NCI)
• Budget Start: 2018-08-01
• Budget End: 2019-07-31
• Support Year: 39
• Fiscal Year: 2018

Institution

• Name: Yale University
• DUNS #: 043207562
• City: New Haven
• State: CT
• Country: United States

Publications

Jagannath, Sundar; Laubach, Jacob; Wong, Ellice et al. (2018) Elotuzumab monotherapy in patients with smouldering multiple myeloma: a phase 2 study. Br J Haematol 182:495-503

Liu, Xiaoni; Zhang, Shang-Min; McGeary, Meaghan K et al. (2018) KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations. Mol Cancer Ther :

Chae, Wook-Jin; Bothwell, Alfred L M (2018) Therapeutic Potential of Gene-Modified Regulatory T Cells: From Bench to Bedside. Front Immunol 9:303

Kim, Hanseul; Keum, NaNa; Giovannucci, Edward L et al. (2018) Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies. Int J Cancer 143:1047-1053

Sarma, Elizabeth A; Kawachi, Ichiro; Poole, Elizabeth M et al. (2018) Social integration and survival after diagnosis of colorectal cancer. Cancer 124:833-840

Hartman, Douglas J; Ahmad, Fahad; Ferris, Robert L et al. (2018) Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma. Oral Oncol 86:278-287

Chen, Ling; Azuma, Takeshi; Yu, Weiwei et al. (2018) B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Proc Natl Acad Sci U S A 115:3126-3131

Zhang, Jinhua; Song, Kun; Wang, Jun et al. (2018) S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity. Oncoimmunology 7:e1296996

Kelada, Olivia J; Decker, Roy H; Nath, Sameer K et al. (2018) High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors. Int J Radiat Oncol Biol Phys 102:174-183

Powles, Ryan L; Redmond, David; Sotiriou, Christos et al. (2018) Association of T-Cell Receptor Repertoire Use With Response to Combined Trastuzumab-Lapatinib Treatment of HER2-Positive Breast Cancer: Secondary Analysis of the NeoALTTO Randomized Clinical Trial. JAMA Oncol 4:e181564