Since its establishment in 1978, the Biostatistics Unit has been continuously funded by the NCI Core Grant. During the current project period, the Biostatistics Unit has been fully reorganized and a number of highly experienced faculty and staff biostatisticians have been recruited. In 1996, Jesse Berlin, ScD, Associate Professor of Biostatistics and Epidemiology, was appointed. Facility Director to lead this reorganization and expansion. In mid-1997, J. Richard Landis, PhD, a national expert in large scale, multi-center data coordinating projects, was recruited to Penn as Director of the Division of Biostatistics and Associate Director of the Biostatistics Unit. He significantly expanded the capabilities of the Cancer Center Biostatistics Unit to include comprehensive computing resources that are required to support cancer research projects involving the collection and analysis of extensive data. Instrumental to these changes was the senior leadership provided by John H. Glick, MD, Cancer Center Director, and Brian L. Strom, MD, MPH, a long-standing Cancer Center member who was appointed the first Chair of the Department of Biostatistics and Epidemiology in 1995. Considerable institutional and Cancer Center non-Core Grant resources as well as Departmental support have contributed to the recruitment of new biostatistics faculty and staff, new and expanded facilities and extensive statistical computing capabilities. Today, the research projects in multiple Cancer Center Research Programs. It plays an integral role within the Cancer Center's Clinical Trials Scientific Review and Monitoring Committee with a high degree of representation and authority. A significant number of the grant applications that received biostatistical input from the Biostatistics Unit during the current period have subsequently received peer-reviewed funding. This includes four NIH P01s. Based on internal and expert external reviews conducted by the Cancer Center since the reorganization, the new Biostatistics Unit has become an outstanding, well-utilized and respected Shared Resource that contributes significantly to the successful competition of peer-reviewed grant applications requiring high quality biostatistical support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016520-27
Application #
6573822
Study Section
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
27
Fiscal Year
2002
Total Cost
$228,564
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Fraietta, Joseph A; Lacey, Simon F; Orlando, Elena J et al. (2018) Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nat Med 24:563-571
Shroff, Rachna T; Hendifar, Andrew; McWilliams, Robert R et al. (2018) Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation. JCO Precis Oncol 2018:
Williams, Austin D; Reyes, Sylvia A; Arlow, Renee L et al. (2018) Is Age Trumping Genetic Profiling in Clinical Practice? Relationship of Chemotherapy Recommendation and Oncotype DX Recurrence Score in Patients Aged Ann Surg Oncol 25:2875-2883
Anton, Lauren; Sierra, Luz-Jeannette; DeVine, Ann et al. (2018) Common Cervicovaginal Microbial Supernatants Alter Cervical Epithelial Function: Mechanisms by Which Lactobacillus crispatus Contributes to Cervical Health. Front Microbiol 9:2181
Krump, Nathan A; Liu, Wei; You, Jianxin (2018) Mechanisms of persistence by small DNA tumor viruses. Curr Opin Virol 32:71-79
Bengsch, Bertram; Ohtani, Takuya; Khan, Omar et al. (2018) Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity 48:1029-1045.e5
Nair, Praful R; Alvey, Cory; Jin, Xiaoling et al. (2018) Filomicelles Deliver a Chemo-Differentiation Combination of Paclitaxel and Retinoic Acid That Durably Represses Carcinomas in Liver to Prolong Survival. Bioconjug Chem 29:914-927
Bhagwat, Neha; Dulmage, Keely; Pletcher Jr, Charles H et al. (2018) An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters. Sci Rep 8:5035
Raposo-Ferreira, Talita M M; Brisson, Becky K; Durham, Amy C et al. (2018) Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Vet Pathol 55:622-633
Kasner, Margaret T; Mick, Rosemarie; Jeschke, Grace R et al. (2018) Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition. Invest New Drugs 36:657-666

Showing the most recent 10 out of 1047 publications