The Hematologic Malignancies Program (HMP) was established in 1995 as the Stem Cell Biology and Therapeutics Program. It was given its present name in 2004 to better reflect the overarching mission of the HMP, i.e. to translate basic scientific discoveries into novel therapeutics for patients with myeloid and lymphoid neoplasms. To support this mission, the HMP has 5 scientific goals. These are to: 1) develop a mechanistic understanding of the role of chromosomal translocations, chromatin remodeling, and transcription factors in regulating normal and malignant hematopoiesis;2) define the receptors and signal transduction pathways employed by malignant hematopoietic cells to respond to specific environmental stimuli;3) investigate the immune response to these cells to develop more effective immune-based therapies;4) create animal models to test promising discoveries coming from the laboratory;and 5) design and conduct innovative, field-leading clinical trials. The Program has been led for the past decade by Alan M. Gewirtz, MD, a pioneer of translational research in the hematologic malignancies. Dr. Edward Stadtmauer, a leader in clinical trials of novel therapeutics for hematologic malignancies and bone marrow transplantation, has served as Co-Leader for the past 2 years. The HMP has 19 primary members, drawn from 5 Departments (Medicine, Pediatrics, Genetics, Pathology, Cancer Cell Biology) within the University of Pennsylvania School of Medicine, who share a strong research interest in the molecular, cellular, structural, biochemical and immunological approaches to understanding blood cancers and their treatment. HMP member interactions are facilitated by common use of Cores, multiple weekly seminars and meetings, collaborative grant submissions, and an annual research retreat. During the last budget period, a total of 38 peer reviewed projects were supported by NCI, NIH, and other non-governmental agencies (LLS, ACS) for a total of $5,693,859 in research funding (annual direct costs) of which $4,927,175 is peer-reviewed and $2,652,239 is from the NCI. During the last review period, HMP members published 333 cancer-related papers. Of these, 13% were intra-programmatic collaborations and 42% resulted from inter-programmatic collaborations.

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National Cancer Institute (NCI)
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Subcommittee G - Education (NCI)
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Shroff, Rachna T; Hendifar, Andrew; McWilliams, Robert R et al. (2018) Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation. JCO Precis Oncol 2018:
Fraietta, Joseph A; Lacey, Simon F; Orlando, Elena J et al. (2018) Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nat Med 24:563-571
Anton, Lauren; Sierra, Luz-Jeannette; DeVine, Ann et al. (2018) Common Cervicovaginal Microbial Supernatants Alter Cervical Epithelial Function: Mechanisms by Which Lactobacillus crispatus Contributes to Cervical Health. Front Microbiol 9:2181
Williams, Austin D; Reyes, Sylvia A; Arlow, Renee L et al. (2018) Is Age Trumping Genetic Profiling in Clinical Practice? Relationship of Chemotherapy Recommendation and Oncotype DX Recurrence Score in Patients Aged Ann Surg Oncol 25:2875-2883
Krump, Nathan A; Liu, Wei; You, Jianxin (2018) Mechanisms of persistence by small DNA tumor viruses. Curr Opin Virol 32:71-79
Bengsch, Bertram; Ohtani, Takuya; Khan, Omar et al. (2018) Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity 48:1029-1045.e5
Nair, Praful R; Alvey, Cory; Jin, Xiaoling et al. (2018) Filomicelles Deliver a Chemo-Differentiation Combination of Paclitaxel and Retinoic Acid That Durably Represses Carcinomas in Liver to Prolong Survival. Bioconjug Chem 29:914-927
Bhagwat, Neha; Dulmage, Keely; Pletcher Jr, Charles H et al. (2018) An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters. Sci Rep 8:5035
Raposo-Ferreira, Talita M M; Brisson, Becky K; Durham, Amy C et al. (2018) Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Vet Pathol 55:622-633
Kasner, Margaret T; Mick, Rosemarie; Jeschke, Grace R et al. (2018) Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition. Invest New Drugs 36:657-666

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