Protocol review and monitoring within the Abramson Cancer Center (ACC) is undertaken by the Clinical Trials Scientific Review and Monitoring Committee (CTSRMC), Co-Chaired by Sunita Nasta, MD and John Plastaras, MD, PhD. The ACC continuously evaluates the structure, operations, quality, and conduct of its Protocol Review and Monitoring System. CTSRMC membership is evaluated yearly to ensure well-rounded and appropriate expertise in all aspects of cancer clinical research, which enables the Committee to conduct thorough and meaningful peer-review of proposed research protocols. In addition to scientific peer-review, the Committee undertakes evaluation of study feasibility and prioritization by each disease program as well as post-approval accrual and scientific progress. This promotes collaboration within the clinical programs and prevents duplication of effort, eliminates underperforming protocols, and facilitates effective resource utilization. By providing critical scientific review of protocols, the CTSRMC also supports the ACC's commitment to conducting innovative, scientifically progressive research. The Committee is supported by experienced senior administrative staff dedicated to operational quality and efficiency, allowing protocols to be reviewed and monitored in a timely fashion. The CTSRMC has implemented a customized web-based Clinical Trials Management System for tracking all cancer-related research conducted at the University of Pennsylvania. This system is used by all research teams to register protocols and subjects as well as to manage their day-to-day study support and data collection needs. The Clinical Trials Management System ties research teams together: improving information sharing, data quality, and subject safety. Through rigorous scientific review of merit, priority, and progress of cancer-related research, the CTSRMC has established itself as an integral, valued, and respected peer review body.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
United States
Zip Code
Ecker, Christopher; Guo, Lili; Voicu, Stefana et al. (2018) Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments. Cell Rep 23:741-755
Alexander, Erica S; Mick, Rosemarie; Nadolski, Gregory J et al. (2018) Combined chemoembolization and thermal ablation for the treatment of metastases to the liver. Abdom Radiol (NY) 43:2859-2867
Liu, Wei; Krump, Nathan A; MacDonald, Margo et al. (2018) Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts. J Virol 92:
Schapira, Marilyn M; Barlow, William E; Conant, Emily F et al. (2018) Communication Practices of Mammography Facilities and Timely Follow-up of a Screening Mammogram with a BI-RADS 0 Assessment. Acad Radiol 25:1118-1127
Morrison, Alexander H; Byrne, Katelyn T; Vonderheide, Robert H (2018) Immunotherapy and Prevention of Pancreatic Cancer. Trends Cancer 4:418-428
Ojha, Rani; Leli, Nektaria M; Onorati, Angelique et al. (2018) ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma. Cancer Discov :
Yan, Lesan; Amirshaghaghi, Ahmad; Huang, Dennis et al. (2018) Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy. Adv Funct Mater 28:
Waxman, Adam J; Clasen, Suparna; Hwang, Wei-Ting et al. (2018) Carfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-analysis. JAMA Oncol 4:e174519
Han, Joseph; Lachance, Catherine; Ricketts, M Daniel et al. (2018) The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate. J Biol Chem 293:4498-4509
Gangadhar, Tara C; Savitch, Samantha L; Yee, Stephanie S et al. (2018) Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma. Pigment Cell Melanoma Res 31:73-81

Showing the most recent 10 out of 1047 publications