? Tobacco and Environmental Carcinogenesis (TEC) Program The Tobacco and Environmental Carcinogenesis (TEC) Program, which received a ranking of ?Exceptional? merit in the 2015 CCSG submission, includes 17 members from six departments within the Perelman School of Medicine (Psychiatry, Medicine, Systems Pharmacology and Translational Therapeutics, Dermatology, Pediatrics, and Neuroscience) and from the School of Nursing and the Annenberg School of Communication, who elucidate how exposure to tobacco and environmental carcinogens cause cancer and how these exposures can be mitigated by risk reduction, intervention, and communication-based intervention strategies. The TEC Program is particularly focused on tobacco-related cancers, asbestos exposure and mesothelioma, and has a new effort in UV/light exposure and skin cancer. These research areas provide rich opportunities for inter- and intra-Programmatic research. TEC Program Leaders are Dr. Trevor Penning, an expert in environmental carcinogenesis, and Dr. Robert Schnoll, a leader in tobacco control, who together champion a translational and transdisciplinary vision for TEC. The scientific aims of the Program are to: 1) elucidate the pathways underlying exposure risk (e.g., risk factors for tobacco dependence; risk of environmental exposures for mesothelioma, lung cancer and skin cancer); 2) identify the mechanisms linking exposure to disease; 3) evaluate methods for exposure and risk reduction (e.g., tobacco cessation treatments; asbestos remediation; UV light protection); and 4) test methods of risk communication (e.g., tobacco marketing, regulatory science). The Program has 13 R01-equivalents. Program members accrued 1,642 subjects to interventional treatment trials and 2,776 subjects to non-interventional trials. As one of the two Population Science Programs, TEC Program members collaborate within TEC and across the Cancer Control, Cancer Therapeutics, Tumor Biology, Radiobiology and Imaging (RBI), and Immunobiology Programs and engage in population and community-based research within the Abramson Cancer Center (ACC) catchment area. TEC also leads transformative educational experiences across Penn and the catchment area. Seminal contributions during the project period include illustrating the potential use of low-nicotine content cigarettes as a national regulatory mechanism to reduce smoking rates and identifying novel mechanisms by which petrogenic polycyclic aromatic hydrocarbons in the environment are metabolically activated. The intra- and inter-Programmatic environment is facilitated by mentoring, symposia, working groups, and pilot grants. TEC has $5M in cancer- related grants (direct), of which $2.6M is from NCI and $4.8M is peer-reviewed. Collaborative grants include an NCI U54 Tobacco Center of Regulatory Science (with Cancer Control), a P30 Center of Excellence in Environmental Toxicology (CEET; with Cancer Control), and a NIDA funded P30 PET Addiction Center of Excellence (PACE; with RBI). Members have authored 316 cancer-related publications (21% intra- Programmatic; 22% inter-Programmatic; 78% multi-Institutional) during the current period.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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University of Pennsylvania
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Chang, Changgee; Kundu, Suprateek; Long, Qi (2018) Scalable Bayesian variable selection for structured high-dimensional data. Biometrics :
Min, Eun Jeong; Safo, Sandra E; Long, Qi (2018) Penalized Co-Inertia Analysis with Applications to -Omics Data. Bioinformatics :
Singh, Rajnish Kumar; Lang, Fengchao; Pei, Yonggang et al. (2018) Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia. PLoS Pathog 14:e1007062
Pei, Yonggang; Singh, Rajnish Kumar; Shukla, Sanket Kumar et al. (2018) Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2. J Virol 92:
Nicastri, Michael C; Rebecca, Vito W; Amaravadi, Ravi K et al. (2018) Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells. Mol Cell Oncol 5:e1395504
Micallef, Ivana N; Stiff, Patrick J; Nademanee, Auayporn P et al. (2018) Plerixafor Plus Granulocyte Colony-Stimulating Factor for Patients with Non-Hodgkin Lymphoma and Multiple Myeloma: Long-Term Follow-Up Report. Biol Blood Marrow Transplant 24:1187-1195
Medvec, Andrew R; Ecker, Christopher; Kong, Hong et al. (2018) Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium. Mol Ther Methods Clin Dev 8:65-74
Acosta, Jonuelle; Wang, Walter; Feldser, David M (2018) Off and back-on again: a tumor suppressor's tale. Oncogene 37:3058-3069
Crisalli, Lisa M; Hinkle, Joanne T; Walling, Christopher C et al. (2018) Higher Donor Apheresis Blood Volumes Are Associated with Reduced Relapse Risk and Improved Survival in Reduced-Intensity Allogeneic Transplantations with Unrelated Donors. Biol Blood Marrow Transplant 24:1203-1208
Mazaleuskaya, Liudmila L; Salamatipour, Ashkan; Sarantopoulou, Dimitra et al. (2018) Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J Lipid Res 59:564-575

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