- Community Outreach and Engagement (COE) Community Outreach and Engagement (COE) is a longstanding priority of the Abramson Cancer Center (ACC) and leverages decades of commitment to address the cancer burden in our catchment area. COE's mission is to engage with the catchment area community; understand the cancer burden in the catchment area; ensure that our Research Programs work to reduce cancer burdens; and disseminate evidence-based interventions and policies in our catchment area and beyond. Leading our COE are two highly skilled and experienced population scientists: Dr. Karen Glanz, Associate Director (AD) for Community-Engaged Research, and Dr. Carmen Guerra, AD for Diversity and Outreach, who, together, bring the expertise and dedication needed to achieve the COE mission. They led the effort to comprehensively characterize our catchment area, a geographically-defined area of 12 contiguous counties in Southeastern Pennsylvania, New Jersey, and Delaware, with over 7 million residents, which captures the residences of 81.4% of all ACC patients seen during the current funding period. The ACC has invested heavily to systematically understand the unique cancer burdens, including cancer incidence and mortality rates, disparities, and cancer-related risk factors across the catchment area. Key aspects of the cancer burden in the catchment area include: a high overall cancer incidence; high incidence of prostate, lung, pancreas, and liver cancers, melanoma, and non-Hodgkin's lymphoma; variable cancer incidence between Philadelphia County (lung, liver) and the other counties in the catchment area (breast, prostate, melanoma); differential cancer incidence and mortality between Black (lung, liver) vs. White (breast, prostate, melanoma) catchment area residents; many medically underserved residents, particularly in Philadelphia; areas with concentrated carcinogenic environmental hazards; and high rates of obesity, smoking, and alcohol use. COE leaders manage a bidirectional process of communication, working with the Community Advisory Board, ACC leadership, and Program Leaders to understand catchment area needs, in order to shape research and outreach to reduce the cancer burden. COE uses a logic model as a conceptual framework to guide its activities, objectives, and evaluation of impact. During the current funding period, COE developed new tools (the ACC Catchment Explorer and Catchment Report) and catalyzed research to ensure an emphasis on data-driven priorities. Significant impacts of COE to date include achieving high rates of minority participation in clinical trials, accelerating uptake of early cancer detection methods, promoting high rates of HPV vaccination, and increasing tobacco use treatment. The accomplishments of COE to date reflect the ACC's deep commitment to community engagement, catchment area-relevant research, and the dissemination of cancer prevention information and policies that directly affect the ACC catchment area.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016520-45
Application #
10088752
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-15
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Shroff, Rachna T; Hendifar, Andrew; McWilliams, Robert R et al. (2018) Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation. JCO Precis Oncol 2018:
Fraietta, Joseph A; Lacey, Simon F; Orlando, Elena J et al. (2018) Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nat Med 24:563-571
Anton, Lauren; Sierra, Luz-Jeannette; DeVine, Ann et al. (2018) Common Cervicovaginal Microbial Supernatants Alter Cervical Epithelial Function: Mechanisms by Which Lactobacillus crispatus Contributes to Cervical Health. Front Microbiol 9:2181
Williams, Austin D; Reyes, Sylvia A; Arlow, Renee L et al. (2018) Is Age Trumping Genetic Profiling in Clinical Practice? Relationship of Chemotherapy Recommendation and Oncotype DX Recurrence Score in Patients Aged Ann Surg Oncol 25:2875-2883
Krump, Nathan A; Liu, Wei; You, Jianxin (2018) Mechanisms of persistence by small DNA tumor viruses. Curr Opin Virol 32:71-79
Bengsch, Bertram; Ohtani, Takuya; Khan, Omar et al. (2018) Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity 48:1029-1045.e5
Nair, Praful R; Alvey, Cory; Jin, Xiaoling et al. (2018) Filomicelles Deliver a Chemo-Differentiation Combination of Paclitaxel and Retinoic Acid That Durably Represses Carcinomas in Liver to Prolong Survival. Bioconjug Chem 29:914-927
Bhagwat, Neha; Dulmage, Keely; Pletcher Jr, Charles H et al. (2018) An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters. Sci Rep 8:5035
Raposo-Ferreira, Talita M M; Brisson, Becky K; Durham, Amy C et al. (2018) Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Vet Pathol 55:622-633
Kasner, Margaret T; Mick, Rosemarie; Jeschke, Grace R et al. (2018) Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition. Invest New Drugs 36:657-666

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