? Developmental Funds During the current project period, the Abramson Cancer Center (ACC) used Developmental Funds to support innovative new research through a robust Pilot Project Program, to support our Staff Investigators, to support our Developing Shared Resources, and to support new and talented faculty recruits. These funds stimulated research in areas of strategic importance to the ACC. This support is essential to the ACC's ability to execute its responsibilities in stimulating transdisciplinary and translational research and to encourage research in areas of priority to both the ACC and the NCI. Pilot awards are issued based on a long-standing, well- established peer-review process involving senior and junior ACC members from multiple Programs, departments, and disciplines. This process is similar to the peer-review process used by the NCI. During the current project period plus the last two years of the previous project period, 34 pilot projects were awarded. Fifteen new externally funded grants were awarded to pilot recipients (totaling $14.3M in direct costs) and another three external grants are pending review. Additionally, this work was disseminated to peers through 31 manuscripts in high-impact journals including Nature, Nature Medicine, JAMA, Cancer Discovery, and J Clin Onc. Other noteworthy outcomes from our pilots include performance of nine interventional clinical trials and launching of a Translational Center of Excellence in Cardio-Oncology and the Population Science Center of Excellence in lung cancer screening. Developmental Funds during the current cycle supported three Staff Investigators and two Developing Shared Resources (one in Circulating Tumor Material and one in Cancer Metabolism). Both Developing Shared Resources supported multiple high-impact publications (including papers in Nature, Cell, JCI, and PNAS), and services are now incorporated into full Shared Resources in this renewal application. Finally, Developmental Funds were used to aid in the recruitment of three talented faculty members (Dr. Kathrin Bernt, Pediatric Oncology; Dr. Kara Maxwell, Cancer Control; and Dr. Robert Maki, who arrived at Penn in 2020). In the coming cycle, we are requesting Developmental Funds to continue our Pilot Project Program, to provide support for two Staff Investigators, and to continue our recruitment of faculty-level scientists in areas of strategic need.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016520-45
Application #
10088753
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-15
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hinderer, Christian; Katz, Nathan; Buza, Elizabeth L et al. (2018) Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN. Hum Gene Ther 29:285-298
Li, Jinyang; Byrne, Katelyn T; Yan, Fangxue et al. (2018) Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy. Immunity 49:178-193.e7
Raghunathan, Nirupa Jaya; Korenstein, Deborah; Li, Qing S et al. (2018) Determinants of mobile technology use and smartphone application interest in cancer patients. Cancer Med 7:5812-5819
Hordeaux, Juliette; Wang, Qiang; Katz, Nathan et al. (2018) The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice. Mol Ther 26:664-668
Echevarría-Vargas, Ileabett M; Reyes-Uribe, Patricia I; Guterres, Adam N et al. (2018) Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. EMBO Mol Med 10:
Torre, Eduardo; Dueck, Hannah; Shaffer, Sydney et al. (2018) Rare Cell Detection by Single-Cell RNA Sequencing as Guided by Single-Molecule RNA FISH. Cell Syst 6:171-179.e5
Vonderheide, Robert H (2018) The Immune Revolution: A Case for Priming, Not Checkpoint. Cancer Cell 33:563-569
Romero, Sally A D; Jones, Lee; Bauml, Joshua M et al. (2018) The association between fatigue and pain symptoms and decreased physical activity after cancer. Support Care Cancer 26:3423-3430
Kall, Stefanie L; Delikatny, Edward J; Lavie, Arnon (2018) Identification of a Unique Inhibitor-Binding Site on Choline Kinase ?. Biochemistry 57:1316-1325
Safo, Sandra E; Li, Shuzhao; Long, Qi (2018) Integrative analysis of transcriptomic and metabolomic data via sparse canonical correlation analysis with incorporation of biological information. Biometrics 74:300-312

Showing the most recent 10 out of 1047 publications