? Shared Resource Management The ACC Shared Resources provide access to specialized technologies, services, training and expertise critical to accelerate research productivity for the 324 ACC members. Each Shared Resource engages with ACC members, trainees, and staff to catalyze basic, translational, clinical and population science cancer research, provide user training and support grant applications for extramural funding and publication of high impact papers. Under the direction of Dr. Celeste Simon, Associate Director for Shared Resources, they are continuously evaluated to ensure that they provide cutting edge technologies and accessible, cost-effective and reliable services that serve the needs of the ACC membership. We propose the following three aims: 1) Support high quality Shared Resources that serve the scientific needs of the ACC membership and catalyze impactful research activity; 2) Ensure stability of and access to ACC and institutional Shared Resources through responsible fiscal management and over-arching usage policies; and 3) Determine the scientific priorities of ACC members and ensure current and future Shared Resources meet membership needs. ACC Administration works closely with ACC Leadership and Dr. Simon in assessing Shared Resources, overseeing management, and ensuring fiscal stability, cost-effectiveness and opportunities for growth. Fiscal oversight of Shared Resources is accomplished through a suite of applications (Path BioResource system), centrally managed by the Perelman School of Medicine (PSOM) and ACC Administration. Strategic planning is regularly undertaken; user feedback and internal advisory boards for each Shared Resources guarantee cutting-edge quality. The percentage of ACC users for each Shared Resource ranges from 32%-100%; the percentage of annual budget support provided through CCSG to support each Shared Resource ranges from 7% to 34%. For the current funding period, we are proposing nine Full Shared Resources ? ACC BioRepository, Biostatistics and Bioinformatics, Comparative Pathology, Flow Cytometry and Cell Sorting, Genomic Analysis, Human Immunology, Metabolomics, Small Animal Imaging, and Transgenic and Chimeric Mouse Facilities. Based on our strategic planning process and in response to members' scientific needs, two of these Shared Resources (ACC BioRepository; Metabolomics) are new, each emerging from Developing Shared Resources of the current funding period. One existing Shared Resource has been expanded in scope (from the Biostatistics Core to the Biostatistics and Bioinformatics Core). Two Developing Shared Resources (Small Animal Radiation and Electronic Phenotyping) are being proposed, based on ACC membership needs. ACC members can utilize over 75 Core Facilities at PSOM; 24 of these undergo formal review by the PSOM Biomedical Research Core Facilities Committee to assure quality. Through ACC support of Shared Resources, members have access to state-of the-art equipment and instrumentation, technical expertise, training and education, all designed to support innovative cutting-edge cancer research.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Study Section
Subcommittee I - Transistion to Independence (NCI)
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University of Pennsylvania
United States
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Liu, Wei; Krump, Nathan A; MacDonald, Margo et al. (2018) Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts. J Virol 92:
Schapira, Marilyn M; Barlow, William E; Conant, Emily F et al. (2018) Communication Practices of Mammography Facilities and Timely Follow-up of a Screening Mammogram with a BI-RADS 0 Assessment. Acad Radiol 25:1118-1127
Morrison, Alexander H; Byrne, Katelyn T; Vonderheide, Robert H (2018) Immunotherapy and Prevention of Pancreatic Cancer. Trends Cancer 4:418-428
Ojha, Rani; Leli, Nektaria M; Onorati, Angelique et al. (2018) ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma. Cancer Discov :
Yan, Lesan; Amirshaghaghi, Ahmad; Huang, Dennis et al. (2018) Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy. Adv Funct Mater 28:
Waxman, Adam J; Clasen, Suparna; Hwang, Wei-Ting et al. (2018) Carfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-analysis. JAMA Oncol 4:e174519
Han, Joseph; Lachance, Catherine; Ricketts, M Daniel et al. (2018) The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate. J Biol Chem 293:4498-4509
Reshef, Ran; Ganetsky, Alex; Acosta, Edward P et al. (2018) Extended CCR5 Blockade for Graft-versus-Host Disease Prophylaxis Improves Outcomes of Reduced-Intensity Unrelated Donor Hematopoietic Cell Transplantation: A Phase II Clinical Trial. Biol Blood Marrow Transplant :
Gangadhar, Tara C; Savitch, Samantha L; Yee, Stephanie S et al. (2018) Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma. Pigment Cell Melanoma Res 31:73-81
Rosenfeld, Aaron M; Meng, Wenzhao; Luning Prak, Eline T et al. (2018) ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data. Front Immunol 9:2107

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