The Bioinformatics Shared Resource (BISR) provides consultation, collaboration, and support for researchers and core facilities throughout MD Anderson in the statistical analysis and biological interpretation of data from high-throughput pre-clinical technologies. The BISIR has specialist expertise in the bioinformatics of all types of microarrays, next-generation sequencing, mass spectrometry, and flow cytometry. The consultation and collaboration services of the BISR (in hours) have grown 3.1 fold over the past 5 years. The BISR uses a heterogeneous computing environment supported across Windows, Unix/Linux, and Mac OS X operating systems, with access to more than 300 terabytes of in-house storage space for home directories, research data, and data mirrors. It accesses in-house parallel computing capability through a 48-processor Cray XD1 HPC cluster and a 290-processor distributed computing Condor pool of over 160 Windows workstations (each with >2GB of memory) and 8 servers (ranging from 4GB to 16GB of memory). BISR services have been used over the past 5 years by 301 researchers 92% of whom are peer-reviewed cancer center members. Publications cited using the BISR have appeared in Nature, Science, N Engl J Med and J Clin Oncol. Annually, MD Anderson has provided institutional support to the BISR in the amount of $1,244,846. The BISR is requesting funding from the CCSG in the amount of 3% of its total operating budget. In the last 5 years, the BISR has (1) recruited 9 very strong new faculty members from top institutions plus 2 more with joint appointments. It will continue to recruit top bioinformatics faculty and will encourage their participation in multidisciplinary collaborative research to complement their investigator-initiated research;(2) recruited 8 new statistical analysts and 3 biocatalysts to support projects around the institution;(3) created a cadre of 14 postdoctoral fellows, who participate in collaborative research;(4) recruited 4 new programmer/software engineers plus 6 on contract to provide programming strength for its support functions. It will continue to seek talented computer specialists;(5) established a popular hands-on workshop series on bioinformatics tools for MD Anderson biologists and clinical researchers (>500 attendees for 2-hour sessions to date). The BISR will continue to encourage the professional growth of ail of its members through advanced education In bioinformatics and computational skills. It will continue to improve its emerging status as one of the world?s leading bioinformatics groups as we pursue MD Anderson's mission: Making cancer history.

Public Health Relevance

It is now easier; and often cheaper; to generate millions of data points on the molecular profiles of cancers than it is to analyze those data points statistically or interpret them biologically. With the revolution in DNA and RNA sequencing; the need for bioinformatics support throughout MD Anderson has increased exponentially; and the BISR is the institution?s principal resource for dealing with this data deluge.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016672-39
Application #
8759802
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
39
Fiscal Year
2014
Total Cost
$152,370
Indirect Cost
$57,179
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Scruggs, Stacie; Mama, Scherezade K; Carmack, Cindy L et al. (2018) Randomized Trial of a Lifestyle Physical Activity Intervention for Breast Cancer Survivors: Effects on Transtheoretical Model Variables. Health Promot Pract 19:134-144
Wen, Juyi; Liu, Hongliang; Wang, Lili et al. (2018) Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy. J Thorac Oncol 13:660-675
Rivera-Del Valle, Nilsa; Cheng, Tiewei; Irwin, Mary E et al. (2018) Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations. Cancer Chemother Pharmacol 81:483-495
Ohanian, Maro; Rozovski, Uri; Kanagal-Shamanna, Rashmi et al. (2018) MYC protein expression is an important prognostic factor in acute myeloid leukemia. Leuk Lymphoma :1-12
Roman-Gonzalez, Alejandro; Zhou, Shouhao; Ayala-Ramirez, Montserrat et al. (2018) Impact of Surgical Resection of the Primary Tumor on Overall Survival in Patients With Metastatic Pheochromocytoma or Sympathetic Paraganglioma. Ann Surg 268:172-178
Wang, Yugang; Guo, Yusong R; Xing, Dongming et al. (2018) Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation. Cell Discov 4:47
Okuno, Masayuki; Gourmard, Claire; Mizuno, Takashi et al. (2018) Pathological diaphragmatic invasion by colorectal liver metastases is associated with RAS mutation, peritoneal recurrence and worse survival. HPB (Oxford) 20:57-63
Naqvi, Kiran; Cortes, Jorge E; Luthra, Raja et al. (2018) Characteristics and outcome of chronic myeloid leukemia patients with E255K/V BCR-ABL kinase domain mutations. Int J Hematol 107:689-695
Bose, Prithviraj; Nazha, Aziz; Komrokji, Rami S et al. (2018) Mutational landscape of myelodysplastic/myeloproliferative neoplasm-unclassifiable. Blood 132:2100-2103
Loehrer, Andrew P; Chang, David C; Song, Zirui et al. (2018) Health Reform and Utilization of High-Volume Hospitals for Complex Cancer Operations. J Oncol Pract 14:e42-e50

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