HIGH RESOLUTION ELECTRON MICROSCOPY FACILITY (HREMF) The mission of the High Resolution Electron Microscopy Facility (HREMF) is to provide high-quality, affordable electron microscopy services to research investigators at MD Anderson Cancer Center. The facility is in the Smith Research Building and houses a JEOL JEM 1010 transmission electron microscope, a JEOL JSM 5900 scanning electron microscope, a TechnoTrade coating system, a Leica ultramicrotome, and a Leica ultrastainer. Dr. Robert Langley has directed the HREMF for the past 10 years and has 20 years of experience in microscopic imaging of tissues and cells. Kenneth Dunner, Jr, is the manager of the HREMF and is responsible for the daily operations of the facility, including processing and imaging of samples. The HREMF houses the only scanning electron microscope on campus and the only transmission electron microscope that is dedicated to research applications. Since its inception in 1997, the HREMF has received approximately $500,000 in capital equipment funds from MD Anderson. In grant Yr42, 89% of the total usage of the HREMF was by peer-reviewed funded faculty, and we are requesting 55% of the HREMF budget from the CCSG ($106,740). During the past 6 years, the HREMF has provided 6759 hours of service to 164 investigators, 132 of whom were cancer center members representing all 16 CCSG programs. Usage was well distributed among the CCSG programs, and no program accounted for more than 15% of the HREMF's resources. The facility also ranked near the top of a user satisfaction survey and made regular contributions to high-impact publications. The HREMF contributed to 124 publications in peer-reviewed journals, with 88 publications (71%) in journals with IF >5 and 31 publications (25%) in journals with IF >10, including Nature (5 articles), Nat Cell Biol (3 articles), Nat Commun (2 articles), Cancer Cell, Nat Immunol, and Nat Nanotechnol. The HREMF's Specific Aims are:
Aim 1 : To provide MD Anderson Cancer Center investigators with access to microscopy instruments necessary to perform research at the ultrastructural level.
Aim 2 : To provide complete electron microscopy specimen preparation services.
Aim 3 : To provide technical assistance and consultation for electron microscopy applications.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016672-44
Application #
9997802
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
44
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Ji, Shuang; Ning, Jing; Qin, Jing et al. (2018) Conditional independence test by generalized Kendall's tau with generalized odds ratio. Stat Methods Med Res 27:3224-3235
McNeill, Lorna H; Reitzel, Lorraine R; Escoto, Kamisha H et al. (2018) Engaging Black Churches to Address Cancer Health Disparities: Project CHURCH. Front Public Health 6:191
Hosry, Jeff; Miranda, Roberto N; Samaniego, Felipe et al. (2018) Clinicopathologic characteristics and outcomes of transformed diffuse large B-cell lymphoma in hepatitis C virus-infected patients. Int J Cancer 142:940-948
Parkes, Amanda; Clifton, Katherine; Al-Awadhi, Aydah et al. (2018) Characterization of bone only metastasis patients with respect to tumor subtypes. NPJ Breast Cancer 4:2
Raber, Margaret; Huynh, To Nhu; Crawford, Karla et al. (2018) Development and Feasibility of a Community-Based, Culturally Flexible Colorectal Cancer Prevention Program. J Community Health 43:882-885
Wang, Xiaoxiao; Cao, Xin; Sun, Ruifang et al. (2018) Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma. Neoplasia 20:574-593
Koay, Eugene J; Owen, Dawn; Das, Prajnan (2018) Radiation-Induced Liver Disease and Modern Radiotherapy. Semin Radiat Oncol 28:321-331
Zhang, Yan; Coletta, Adriana M; Allen, Pamela K et al. (2018) Perirenal Adiposity is Associated With Lower Progression-Free Survival From Ovarian Cancer. Int J Gynecol Cancer 28:285-292
Rausch, Caitlin R; DiPippo, Adam J; Bose, Prithviraj et al. (2018) Breakthrough Fungal Infections in Patients With Leukemia Receiving Isavuconazole. Clin Infect Dis 67:1610-1613
Gu, Shenda; Ngamcherdtrakul, Worapol; Reda, Moataz et al. (2018) Lack of acquired resistance in HER2-positive breast cancer cells after long-term HER2 siRNA nanoparticle treatment. PLoS One 13:e0198141

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