Abstract

The objectives of this program are to provide for basic and clinical research opportunities and education in the problems of childhood cancer, particularly in terms of gaining new insights into the fundamental aspects of the biology of cancer and its treatment. Currently, this program has provided care for over 5,000 children with cancer. Treatment programs are conducted according to research protocols in order to provide opportunities for continuous improvement of treatment regimens and also to provide necessary data acquisition for development of new knowledge concerning clinical aspects of childhood cancer. In addition, there are five departments of basic laboratory research: Virology/Molecular Biology, Biochemistry, Biochemical and Clinical Pharmacology, Immunology, and Tumor Cell Biology. Many opportunities are being realized for coordinative research involving both clinical and basic cancer center investigators. CORE grant support permits the accomplishments of these objectives within the unique capabilities of St. Jude Children's Research Hospital, the only NCI-sponsored cancer center devoted solely to cancer in children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA021765-14
Application #
3101654
Study Section
Special Emphasis Panel (SRC (15))
Project Start
1977-09-01
Project End
1992-02-29
Budget Start
1991-03-13
Budget End
1992-02-29
Support Year
14
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105

  Publications

van Oosterwijk, Jolieke G; Buelow, Daelynn R; Drenberg, Christina D et al. (2018) Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia. J Clin Invest 128:369-380
Howell, Carrie R; Wilson, Carmen L; Ehrhardt, Matthew J et al. (2018) Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study. Cancer 124:1036-1043
Zamora, Anthony E; Crawford, Jeremy Chase; Thomas, Paul G (2018) Hitting the Target: How T Cells Detect and Eliminate Tumors. J Immunol 200:392-399
Zhong, Bo; Maharaj, Anil; Davis, Abigail et al. (2018) Development and validation of a sensitive LC MS/MS method for the measurement of the checkpoint kinase 1 inhibitor prexasertib and its application in a cerebral microdialysis study. J Pharm Biomed Anal 156:97-103
Upadhyaya, Santhosh A; Robinson, Giles W; Harreld, Julie H et al. (2018) Marked functional recovery and imaging response of refractory optic pathway glioma to BRAFV600E inhibitor therapy: a report of two cases. Childs Nerv Syst 34:605-610
Goldsby, Robert E; Stratton, Kayla L; Raber, Shannon et al. (2018) Long-term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report. Cancer 124:617-625
Howell, Carrie R; Krull, Kevin R; Partin, Robyn E et al. (2018) Randomized web-based physical activity intervention in adolescent survivors of childhood cancer. Pediatr Blood Cancer 65:e27216
Cherian, Milu T; Chai, Sergio C; Wright, William C et al. (2018) CINPA1 binds directly to constitutive androstane receptor and inhibits its activity. Biochem Pharmacol 152:211-223
Hoehn, Mary Ellen; Calderwood, Julie; Gannon, Edwin et al. (2018) Ocular complications in a young pediatric population following bone marrow transplantation. J AAPOS 22:102-106.e1
Devine, Katie A; Mertens, Ann C; Whitton, John A et al. (2018) Factors associated with physical activity among adolescent and young adult survivors of early childhood cancer: A report from the childhood cancer survivor study (CCSS). Psychooncology 27:613-619

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