Abstract

The objective of this program is to conduct basic and clinical research on the problems of childhood cancer that will lead to new insights of the biology of cancer and more effective treatment. Since opening its doors in 1962, this program has provided care for over 10,000 children with cancer. Virtually every patient is treated according to a research protocol in order to provide the best contemporary care, opportunities for improvement of treatment regimens and the necessary data for development of new knowledge concerning clinical aspects of childhood cancer. St. Jude has five departments of basic laboratory research: Virology/Molecular Biology, Biochemistry, Biochemical and Clinical Pharmacology, Immunology, and Tumor Cell Biology. All are engaged in an extensive network of collaborative research involving both clinical and basic cancer center investigators. To enable us to expand our studies further into the etiology of childhood cancer, the Board of Governors has authorized the establishment of a new Department of Genetics. The CORE grant provides support which enables us to accomplish our objectives within the unique capabilities of St. Jude Children's Research Hospital, the only NCI-sponsored cancer center devoted solely to cancer in children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA021765-15
Application #
3101648
Study Section
Cancer Center Support Review Committee (CCS)
Project Start
1977-09-01
Project End
1995-02-28
Budget Start
1992-03-20
Budget End
1993-02-28
Support Year
15
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105

  Publications

Scott, Jessica M; Li, Nan; Liu, Qi et al. (2018) Association of Exercise With Mortality in Adult Survivors of Childhood Cancer. JAMA Oncol 4:1352-1358
Rong, Yongqi; Bansal, Parmil K; Wei, Peng et al. (2018) Glycosylation of Cblns attenuates their receptor binding. Brain Res 1694:129-139
Levine, Jennifer M; Whitton, John A; Ginsberg, Jill P et al. (2018) Nonsurgical premature menopause and reproductive implications in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer 124:1044-1052
Li, Jian-Feng; Dai, Yu-Ting; Lilljebjörn, Henrik et al. (2018) Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Proc Natl Acad Sci U S A 115:E11711-E11720
Sharma, Akshay; Kang, Guolian; Sunkara, Anusha et al. (2018) Haploidentical Donor Transplantation Using a Novel Clofarabine-containing Conditioning Regimen for Very High-risk Hematologic Malignant Neoplasms. J Pediatr Hematol Oncol 40:e479-e485
Waszak, Sebastian M; Northcott, Paul A; Buchhalter, Ivo et al. (2018) Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Lancet Oncol 19:785-798
Zheng, Wenting; O'Hear, Carol E; Alli, Rajshekhar et al. (2018) PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells. Leukemia 32:1157-1167
Heikamp, Emily B; Pui, Ching-Hon (2018) Next-Generation Evaluation and Treatment of Pediatric Acute Lymphoblastic Leukemia. J Pediatr 203:14-24.e2
Sadighi, Zsila S; Curtis, Elizabeth; Zabrowksi, Jennifer et al. (2018) Neurologic impairments from pediatric low-grade glioma by tumor location and timing of diagnosis. Pediatr Blood Cancer 65:e27063
Wierdl, Monika; Tsurkan, Lyudmila; Chi, Liying et al. (2018) Targeting ALK in pediatric RMS does not induce antitumor activity in vivo. Cancer Chemother Pharmacol 82:251-263

Showing the most recent 10 out of 6764 publications