Abstract

The objective of this program is to conduct basic and clinical research on the problems of childhood cancer that will lead to new insights of the biology of cancer and more effective treatment. Since opening its doors in 1962, this program has provided care for over 10,000 children with cancer. Virtually every patient is treated according to a research protocol in order to provide the best contemporary care, opportunities for improvement of treatment regimens and the necessary data for development of new knowledge concerning clinical aspects of childhood cancer. St. Jude has five departments of basic laboratory research: Virology/Molecular Biology, Biochemistry, Biochemical and Clinical Pharmacology, Immunology, and Tumor Cell Biology. All are engaged in an extensive network of collaborative research involving both clinical and basic cancer center investigators. To enable us to expand our studies further into the etiology of childhood cancer, the Board of Governors has authorized the establishment of a new Department of Genetics. The CORE grant provides support which enables us to accomplish our objectives within the unique capabilities of St. Jude Children's Research Hospital, the only NCI-sponsored cancer center devoted solely to cancer in children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA021765-16
Application #
3101655
Study Section
Cancer Center Support Review Committee (CCS)
Project Start
1977-09-01
Project End
1995-02-28
Budget Start
1993-03-01
Budget End
1994-02-28
Support Year
16
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105

  Publications

Ferrolino, Mylene C; Mitrea, Diana M; Michael, J Robert et al. (2018) Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms. Nat Commun 9:5064
Bjornard, Kari L; Gilchrist, Laura S; Inaba, Hiroto et al. (2018) Peripheral neuropathy in children and adolescents treated for cancer. Lancet Child Adolesc Health 2:744-754
Gibson, Todd M; Li, Chenghong; Armstrong, Gregory T et al. (2018) Perceptions of future health and cancer risk in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer 124:3436-3444
Yang, Kai; Blanco, Daniel Bastardo; Chen, Xiang et al. (2018) Metabolic signaling directs the reciprocal lineage decisions of ?? and ?? T cells. Sci Immunol 3:
Kumar, Rahul; Liu, Anthony P Y; Orr, Brent A et al. (2018) Advances in the classification of pediatric brain tumors through DNA methylation profiling: From research tool to frontline diagnostic. Cancer 124:4168-4180
Rusch, Michael; Nakitandwe, Joy; Shurtleff, Sheila et al. (2018) Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome. Nat Commun 9:3962
Luo, Yi; Shao, Lijian; Chang, Jianhui et al. (2018) M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion. Blood Adv 2:859-870
Peterson, Rachel K; Ashford, Jason M; Scott, Sarah M et al. (2018) Predicting parental distress among children newly diagnosed with craniopharyngioma. Pediatr Blood Cancer 65:e27287
Heitzer, Andrew M; Ashford, Jason M; Harel, Brian T et al. (2018) Computerized assessment of cognitive impairment among children undergoing radiation therapy for medulloblastoma. J Neurooncol :
Dove, Austin P; Manole, Bogdan-Alexandru; Wakefield, Daniel V et al. (2018) Managing local-regional failure in children with high-risk neuroblastoma: A single institution experience. Pediatr Blood Cancer 65:e27408

Showing the most recent 10 out of 6764 publications