of Shared ResourceThe Bioinformatics & Biotechnology Shared Resource provides a broad range of chemistry, biomolecular, andbioinformatics services and expertise in support of Cancer Center research programs. It includesBioinformatics, High-throughput DMA Sequencing & Genotyping, Functional Genomics, and Proteomics.Bioinformatics provides investigators with access to high-performance computing resources, bioinformaticssoftware, a software and database development group, and a staff of 10 Ph.D.-level bioinformatics experts.High-throughput DNA Sequencing & Genotyping provides investigators with access to automated DMAsequence analysis, fragment size analysis, and SNP detection technologies. Functional Genomics providescDNA and Affymetrix microarray services and analyses to Center investigators. Proteomics offers a range ofprotein chemistry capabilities including protein identification from a gel slice or spot; protein identification froma solution by LC-MS/MS; Intact mass measurement; and 2D-gel analysis. All of these resources are highlyintegrated and readily accessible using our Web-based on-line ordering, tracking, invoicing, and data retrievalsystem. In total, this shared resource staffing is now at 68 FTEs including 22 Ph.D.'s representing alldisciplines encompassed by the Shared Resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA021765-30
Application #
7714153
Study Section
Special Emphasis Panel (ZCA1-RTRB-Z (O1))
Project Start
2008-06-14
Project End
2013-02-28
Budget Start
2008-06-14
Budget End
2009-02-28
Support Year
30
Fiscal Year
2008
Total Cost
$536,297
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Brinkman, Tara M; Ness, Kirsten K; Li, Zhenghong et al. (2018) Attainment of Functional and Social Independence in Adult Survivors of Pediatric CNS Tumors: A Report From the St Jude Lifetime Cohort Study. J Clin Oncol 36:2762-2769
Phillips, Aaron H; Ou, Li; Gay, Alexandre et al. (2018) Mapping Interactions between p27 and RhoA that Stimulate Cell Migration. J Mol Biol 430:751-758
Roussel, Martine F; Stripay, Jennifer L (2018) Epigenetic Drivers in Pediatric Medulloblastoma. Cerebellum 17:28-36
Youn, Yong Ha; Han, Young-Goo (2018) Primary Cilia in Brain Development and Diseases. Am J Pathol 188:11-22
Hammill, Jared T; Scott, Daniel C; Min, Jaeki et al. (2018) Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem 61:2680-2693
Alexander, Thomas B; Gu, Zhaohui; Iacobucci, Ilaria et al. (2018) The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature 562:373-379
Monahan, Ken; Lenihan, Daniel; Brittain, Evan L et al. (2018) The relationship between pulmonary artery wedge pressure and pulmonary blood volume derived from contrast echocardiography: A proof-of-concept study. Echocardiography 35:1266-1270
Upadhyaya, Santhosh A; Ghazwani, Yahya; Wu, Shengjie et al. (2018) Mortality in children with low-grade glioma or glioneuronal tumors: A single-institution study. Pediatr Blood Cancer 65:
Armstrong, Gregory T; Tolle, James J; Piana, Robert et al. (2018) Exercise right heart catheterization for pulmonary hypertension identified on screening echocardiography in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort. Pediatr Blood Cancer 65:
Lin, Wenwei; Chen, Taosheng (2018) Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction. Adv Protein Chem Struct Biol 110:31-63

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