Abstract

of Shared Resource The Bioinformatics &Biotechnology Shared Resource provides a broad range of chemistry, biomolecular, and bioinformatics services and expertise in support of Cancer Center research programs. It includes Bioinformatics, High-throughput DMA Sequencing &Genotyping, Functional Genomics, and Proteomics. Bioinformatics provides investigators with access to high-performance computing resources, bioinformatics software, a software and database development group, and a staff of 10 Ph.D.-level bioinformatics experts. High-throughput DNA Sequencing &Genotyping provides investigators with access to automated DMA sequence analysis, fragment size analysis, and SNP detection technologies. Functional Genomics provides cDNA and Affymetrix microarray services and analyses to Center investigators. Proteomics offers a range of protein chemistry capabilities including protein identification from a gel slice or spot;protein identification from a solution by LC-MS/MS;Intact mass measurement;and 2D-gel analysis. All of these resources are highly integrated and readily accessible using our Web-based on-line ordering, tracking, invoicing, and data retrieval system. In total, this shared resource staffing is now at 68 FTEs including 22 Ph.D.'s representing all disciplines encompassed by the Shared Resource.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA021765-31
Application #
7802171
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2009-03-01
Budget End
2010-02-28
Support Year
31
Fiscal Year
2009
Total Cost
$976,250
Indirect Cost

  Institution

Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105

  Publications

Gibson, Todd M; Li, Chenghong; Armstrong, Gregory T et al. (2018) Perceptions of future health and cancer risk in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer 124:3436-3444
Yang, Kai; Blanco, Daniel Bastardo; Chen, Xiang et al. (2018) Metabolic signaling directs the reciprocal lineage decisions of ?? and ?? T cells. Sci Immunol 3:
Ferrolino, Mylene C; Mitrea, Diana M; Michael, J Robert et al. (2018) Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms. Nat Commun 9:5064
Bjornard, Kari L; Gilchrist, Laura S; Inaba, Hiroto et al. (2018) Peripheral neuropathy in children and adolescents treated for cancer. Lancet Child Adolesc Health 2:744-754
Luo, Yi; Shao, Lijian; Chang, Jianhui et al. (2018) M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion. Blood Adv 2:859-870
Peterson, Rachel K; Ashford, Jason M; Scott, Sarah M et al. (2018) Predicting parental distress among children newly diagnosed with craniopharyngioma. Pediatr Blood Cancer 65:e27287
Kumar, Rahul; Liu, Anthony P Y; Orr, Brent A et al. (2018) Advances in the classification of pediatric brain tumors through DNA methylation profiling: From research tool to frontline diagnostic. Cancer 124:4168-4180
Rusch, Michael; Nakitandwe, Joy; Shurtleff, Sheila et al. (2018) Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome. Nat Commun 9:3962
Kurmasheva, Raushan T; Kurmashev, Dias; Reynolds, C Patrick et al. (2018) Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 65:
Chamdine, Omar; Elhawary, Ghada Ahmad Saad; Alfaar, Ahmad Samir et al. (2018) The incidence of brainstem primitive neuroectodermal tumors of childhood based on SEER data. Childs Nerv Syst 34:431-439

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